Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/111962
Genetic variants of innate immune receptors and infections after liver transplantation.
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Toll-like receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.
Matèries
Matèries (anglès)
Citació
Citació
SANCLEMENTE, Gemma, MORENO CAMACHO, Ma. asunción, NAVASA, Miquel, LOZANO SOTO, Francisco, CERVERA, Carlos. Genetic variants of innate immune receptors and infections after liver transplantation.. _World Journal of Gastroenterology_. 2014. Vol. 20, núm. 32, pàgs. 11116-11130. [consulta: 21 de gener de 2026]. ISSN: 1007-9327. [Disponible a: https://hdl.handle.net/2445/111962]