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2014-08-28

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cc-by-nc (c) Sanclemente, Gemma et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/111962

Genetic variants of innate immune receptors and infections after liver transplantation.

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https://doi.org/10.3748/wjg.v20.i32.11116

Abstract

Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Toll-like receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.

Subject

Trasplantament hepàtic, Morbiditat, Immunitat, Infeccions

Subject (English)

Hepatic transplantation, Morbidity, Immunity, Infections

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

SANCLEMENTE, Gemma, et al. Genetic variants of innate immune receptors and infections after liver transplantation. World Journal of Gastroenterology. 2014. Vol. 20, num. 32, pags. 11116-11130. ISSN 1007-9327. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/111962

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