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2025-02-01

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cc-by-nc-nd (c) Elsevier B.V., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224153

Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia

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The differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. Weconducted a PRISMA 2020-compliant systematic review and random-effects metaanalysis of cohort studies assessing mortality relative risk (RR) for people with schizophrenia, comparing by sex. We measured publication bias and conducted a quality assessment through the Newcastle-Ottawa scale. We meta analyzed 43 studies reporting on 2,700,825 people with schizophrenia. Both males and females with schizophrenia had increased all-cause mortality vs. comparison groups (males, RR=2.62, 95%CI 2.35-2.92; females, RR=2.56, 95%CI 2.27-2.87), suicide (males, RR=9.02, 95%CI 5.96-13.67; females, RR=12.09, 95%CI 9.00-16.25), and natural cause mortality (males, RR=2.11, 95%CI 1.88-2.38; females, RR=2.14, 95%CI 1.93-2.38). No statistically significant differences in sex-dependent mortality risk emerged. There was an age-group-dependent increased mortality risk in females < 40 years vs. >/=40 years old (RR=4.23/2.17), and significantly higher risk of death due to neurological disorders (dementia) in males vs. females (RR=5.19/2.40). Increased mortality risks were often associated with specific modifiable risk factors. There were minimal statistically significant differences in sex-dependent mortality risks in people with schizophrenia. However, it revealed areas of targeted intervention efforts.

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Matèries

Ressenyes sistemàtiques (Investigació mèdica), Antipsicòtics, Mortalitat, Esquizofrènia, Metaanàlisi

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Systematic reviews (Medical research), Antipsychotic drugs, Mortality, Schizophrenia, Meta-analysis

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Articles publicats en revistes (Medicina)

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HØYE, Anne, KOYANAGI, Ai, LARSSON, Henrik, LEHTO, Kelli, LINDGREN, Peter, MANCHIA, Mirko, NORDENTOFT, Merete, SKONIECZNA-ŻYDECKA, Karolina, STUBBS, Brendon, VANCAMPFORT, Davy, BITTER, István, VIETA I PASCUAL, Eduard, GORWOOD, Philip, DE PRISCO, Michele, TAIPALE, Heidi, BOYER, Laurent, TIIHONEN, Jari, HØJLUND, Mikkel, CORTESE, Samuele, CORRELL, Christoph u., DRAGIOTI, Elena, RIETZ, Ebba du, NIELSEN, Rene ernst, FIRTH, Joseph, FUSAR-POLI, Paolo, SOLMI, Marco, CROATTO, Giovanni, FABIANO, Nicholas, WONG, Stanley, GUPTA, Arnav, FORNARO, Michele, SCHNEIDER, Lynne kolton, ROHANI-MONTEZ, S. christy, FAIRLEY, Leanne, SMITH, Nathalie, HARTMAN, Catharina, HOLT, Richard i. g.. Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia. _European Neuropsychopharmacology_. 2025. Vol. 91, núm. 56-66. [consulta: 24 de novembre de 2025]. ISSN: 0924-977X. [Disponible a: https://hdl.handle.net/2445/224153]

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