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2013-06-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/206963

Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of slc7a2 (CAT2) and Leishmania infection is reduced

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https://doi.org/10.1093/infdis/jit084

Resum

Host genetic factors play a crucial role in immune response. To determine whether the differences betweenC57Bl/6 and BALB-C mice are due only to the production of cytokines by T-helper 1 cells or T-helper 2 cells,we obtained bone marrow–derived macrophages from both strains and incubated them with these cytokines.Although the induction of Nos2 and Arg1 was similar in the 2 strains, infectivity to Leishmania major differed,as did macrophage uptake of arginine, which was higher in BALB-C macrophages. The levels of interferon γ–and interleukin 4–dependent induction of the cationic amino acid transporter SLC7A2 (also known as “cationicamino acid transporter 2,” or “CAT2”) were decreased in macrophages from C57Bl/6 mice. This reductionwas a result of a deletion in the promoter of one of the 4 AGGG repeats. These results demonstrate that theavailability of arginine controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection.

Matèries

Macròfags, Leishmània, Aminoàcids

Matèries (anglès)

Macrophages, Leishmania, Amino acids

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citació

SANS-FONS, Gloria, et al. Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of slc7a2 (CAT2) and Leishmania infection is reduced. Journal of Infectious Diseases. 2013. Vol. 207, num. 11, pags. 1684-1693. ISSN 0022-1899. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/206963

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