Miniatura

Fitxers

679772.pdf (731.98 KB)

Tipus de document

Article

Data de publicació

2016-11-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178363

Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.2337/dc16-0614

Resum

OBJECTIVE: Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS: We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125 mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths.RESULTSWe included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) in men; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular non cancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) in men; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS: Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of CSH and PSH provides a comprehensive view of mortality dynamics in a population with diabetes.

Matèries

Diabetis

Matèries (anglès)

Diabetes

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

BAENA DÍEZ, José miguel, PEÑAFIEL, Judith, SUBIRANA, Isaac, RAMOS, Rafel, ELOSUA, Roberto, MARÍN IBÁNEZ, Alejandro, JESÚS GUEMBE, María, RIGO, Fernando, JOSÉ TORMO DÍAZ, Maria, MORENO IRIBAS, Conchi, JOSEP CABRÉ, Joan, SEGURA, Antonio, GARCÍA LAREO, Manel, GOMEZ DE LA CARNARA, Agustin, LAPETRA, José, QUESADA, Miquel, MARRUGAT, Jaume, JOSE MEDRANO, Maria, BERJÓN, Jesus, FRONTERA, Guillem, GAVRILA, Diana, BARRICARTE, Aurelio, BASORA, Josep, MARÍA GARCÍA, Jose, PAVONE, Natalia c., LORA PABLOS, David, MAYORAL, Eduardo, FRANCH NADAL, Josep, MATA CASES, Manel, CASTELL, Conxa, FRANCES, Albert, GRAU, Maria. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. _Diabetes Care_. 2016. Vol. 39, núm. 11, pàgs. 1987-1995. [consulta: 23 de gener de 2026]. ISSN: 0149-5992. [Disponible a: https://hdl.handle.net/2445/178363]

Exportar metadades

JSON - METS

Compartir registre