Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/203046
Integrative epigenomics in chronic lymphocytic leukaemia: Biological insights and clinical applications
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Chronic lymphocytic leukaemia (CLL) is not only characterised by driver genetic alterations but by extensive epigenetic changes. Over the last decade, epigenomic studies have described the DNA methylome, chromatin accessibility, histone modifications and the three-dimensional (3D) genome architecture of CLL. Beyond its regulatory role, the DNA methylome contains imprints of the cellular origin and proliferative history of CLL cells. These two aspects are strong independent prognostic factors. Integrative analyses of chromatin marks have uncovered novel regulatory elements and altered transcription factor networks as non-genetic means mediating gene deregulation in CLL. Additionally, CLL cells display a disease-specific pattern of 3D genome interactions. From the technological perspective, we are currently witnessing a transition from bulk omics to single-cell analyses. This review aims at summarising the major findings from the epigenomics field as well as providing a prospect of the present and future of single-cell analyses in CLL.© 2022 British Society for Haematology and John Wiley & Sons Ltd.
Subject (English)
Citation
Citation
KULIS, Marta and MARTÍN-SUBERO, José Ignacio. Integrative epigenomics in chronic lymphocytic leukaemia: Biological insights and clinical applications. British Journal Of Haematology. 2023. Vol. 200, num. 3, pags. 280-290. ISSN 1365-2141. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/203046