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2023-12-15

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cc-by-nc-nd (c) Rodriguez-Tajes, Sergio et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/218050

The role of HBIG in real life for patients undergoing liver transplantation due to HDV-related cirrhosis

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https://doi.org/10.1111/liv.15777

Resum

Recommended post-liver transplant (LT) prophylaxis in patients with hepatitis delta includes a nucleos(t)ide analogue (NA) and anti-hepatitis B immunoglobulin (HBIG) indefinitely. We analysed the use of HBIG in real-life clinical practice and its impact on HBV/HDV recurrence in 174 HDV-related LT patients from 10 Spanish liver transplant centres (1988-2018). Median post-LT follow-up was 7.8 (2.3-15.1) years and patient survival at 5 years was 90%. Most patients (97%) received HBIG in the immediate post-LT, but only 42% were on HBIG at the last control. Among those discontinuing HBIG, the median time on treatment was 18 (7-52) months. Post-LT HBsAg+ was detected in 16 (9%) patients and HBV-DNA in 12 (7%). Despite HBsAg positivity, HDV recurrence was reported only in three patients (1.7%), all of whom were not receiving NA and had discontinued HBIG. Our data suggest that a finite HBIG prophylaxis in HDV-LT is feasible, especially if high-barrier NAs are used.

Matèries

Hepatitis B, Trasplantament hepàtic, Virus de l'hepatitis delta

Matèries (anglès)

Hepatitis B, Hepatic transplantation, Delta-associated agent

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

RODRIGUEZ-TAJES, Sergio, GARCIA-ELIZ, María, CABALLERO MARCOS, Arantxa, CAMPOS VARELA, Isabel, CACHERO ROS, Alba, LOINAZ, Carmelo, GÓMEZ BRAVO, Miguel ángel, RODRÍGUEZ PERÁLVAREZ, Manuel, FABREGA, Emilio, GONZÁLEZ DIÉGUEZ, María luisa, VINAIXA, Carmen, PASCASIO, Juan manuel, FERNÁNDEZ VÁZQUEZ, Inmaculada, BALIELLAS, Carmen, CASTELLS, Lluís, SALCEDO, Magdalena, PRIETO CASTILLO, Martín, CRESPO CONDE, Gonzalo, LENS GARCÍA, Sabela, FORNS, Xavier. The role of HBIG in real life for patients undergoing liver transplantation due to HDV-related cirrhosis. _Liver International_. 2023. Vol. 44, núm. 2, pàgs. 279-285. [consulta: 23 de gener de 2026]. ISSN: 1478-3223. [Disponible a: https://hdl.handle.net/2445/218050]

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