Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/217865
Lipid-Based Formulation of Baricitinib for the Topical Treatment of Psoriasis
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: Baricitinib, commonly used for autoimmune diseases, is typically administered orally, which can lead to systemic adverse effects. A topical formulation could potentially offer localized therapeutic effects while minimizing these side effects. Objectives: This study focuses on developing a lipid-based topical formulation of baricitinib (BCT-OS) for treating psoriasis. Methods: The optimized formulation was then assessed for physical, chemical, and biopharmaceutical characterization. Furthermore, the anti-inflammatory efficacy of the formulation was tested in a model of psoriasis induced by imiquimod in mice, and its tolerance was determined by the evaluation of biomechanical skin properties and an inflammation test model induced by xylol in mice. Results: BCT-OS presented appropriate characteristics for skin administration in terms of pH, rheology, extensibility, and stability. The formulation also demonstrated a notable reduction in skin inflammation in the mouse model, and high tolerability without affecting the skin integrity. Conclusions: BCT-OS shows promise as an alternative treatment for psoriasis, offering localized therapeutic benefits with a potentially improved safety profile compared to systemic administration.
Matèries
Matèries (anglès)
Citació
Citació
MOHAMMADI-MEYABADI, Roya, MALLANDRICH MIRET, Mireia, BEIRAMPOUR, Negar, GARRÓS, Núria, ESPINOZA TITUANA, Lupe carolina, SOSA DÍAZ, Lilian elisa, SUÑER CARBÓ, J. (joaquim), RODRÍGUEZ LAGUNAS, María josé, GARDUÑO RAMÍREZ, María luisa del carmen, CALPENA CAMPMANY, Ana cristina. Lipid-Based Formulation of Baricitinib for the Topical Treatment of Psoriasis. _Pharmaceutics_. 2024. Vol. 16, núm. 10. [consulta: 28 de gener de 2026]. ISSN: 1999-4923. [Disponible a: https://hdl.handle.net/2445/217865]