Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231534
Exploring the toxicity of mononuclear piano-stool Ru(II) anticancer agents: A comprehensive literature review
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Piano-stool Ru(II) complexes have emerged as a promising class of anticancer agents characterized by structural modularity and diverse cytotoxic activities. The present review consolidates over three decades of research, analyzing IC50 data for 1,449 mononuclear Ru(II) compounds across 151 cancer and healthy cell lines. The whole dataset reveals structure-activity relationships (SAR), emphasizing the role of multidentate ligands – particularly NN-, NO-, and OO-types – and ηn-rings in modulating the biological activity. Compounds with cyclopentadienyl groups often exhibit remarkable effectiveness, achieving sub-micromolar IC50 values and demonstrating efficacy against drug-resistant cancer lines. The bibliographic analysis highlights the versatility of certain ligand combinations, particularly triphenylphosphane with mono- and bidentate ligands, including bipyridine or thioacetamide motifs, which drive exceptional cytotoxic properties. Despite the extensive data set, some gaps remain as some cancer types are underrepresented, and the mechanism(s) of action of the Ru(II)-based cytotoxic agents is(are) not yet fully understood. Future possible research directions within this remarkable family of mononuclear half-sandwich Ru(II) complexes are given.
Matèries (anglès)
Citació
Citació
SOJKA, Martin and GÁMEZ ENAMORADO, Patrick. Exploring the toxicity of mononuclear piano-stool Ru(II) anticancer agents: A comprehensive literature review. Coordination Chemistry Reviews. 2025. Vol. 543. ISSN 0010-8545. [consulted: 18 of September of 2026]. Available at: https://hdl.handle.net/2445/231534