Exploring Partners for the Domino α‐Arylation/Michael Addition Reaction Leading to Tetrahydroisoquinolines

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dc.contributor.authorSolé Arjó, Daniel
dc.contributor.authorPérez Janer, Ferran
dc.contributor.authorGarcía-Rodeja Navarro, Yago
dc.contributor.authorFernández Cadenas, Israel
dc.date.accessioned2019-02-01T12:45:30Z
dc.date.available2019-02-01T12:45:30Z
dc.date.issued2017-01-03
dc.date.updated2019-02-01T12:45:31Z
dc.description.abstractSulfonates, sulfonamides, and phosphonates have proven useful nucleophiles for palladium‐catalyzed intramolecular α‐arylation reactions leading to tetrahydroisoquinolines. Although the sulfonate α‐arylation reaction can be successfully combined in a domino process with a broad range of Michael acceptors, only vinyl sulfones can be used in Michael additions when starting from sulfonamides. No domino process was developed with the phosphonate derivative. DFT calculations were carried out to gain more insights into the experimental differences observed in the reactions involving these substrates.
dc.format.extent7 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec667423
dc.identifier.issn1434-193X
dc.identifier.urihttps://hdl.handle.net/2445/127810
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/ejoc.201601300
dc.relation.ispartofEuropean Journal of Organic Chemistry, 2017, vol. 2017, num. 4, p. 799-805
dc.relation.urihttps://doi.org/10.1002/ejoc.201601300
dc.rights(c) Wiley-VCH, 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationPal·ladi (Element químic)
dc.subject.classificationCatàlisi
dc.subject.classificationSulfamides
dc.subject.classificationTeoria del funcional de densitat
dc.subject.classificationSíntesi orgànica
dc.subject.otherPalladium
dc.subject.otherCatalysis
dc.subject.otherSulfonamides
dc.subject.otherDensity functionals
dc.subject.otherOrganic synthesis
dc.titleExploring Partners for the Domino α‐Arylation/Michael Addition Reaction Leading to Tetrahydroisoquinolines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)