Miniatura

Fitxers

722024.pdf (1.19 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-01-04

Llicència de publicació

cc-by (c) Rouzé, Anahita et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/186710

Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1186/s13054-021-03874-1

Resum

Background: Recent multicenter studies identifed COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and infuenza patients. Objectives: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with infuenza patients. Methods: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Con‑ secutive adult patients requiring invasive mechanical ventilation for>48 h for SARS-CoV-2 pneumonia or infuenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot defnition, was the primary outcome. IPA incidence was estimated using the Kalbfeisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the infuenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in infuenza pneumonia group (29, 6%), adjusted cause-specifc hazard ratio (cHR) 3.29 (95% CI 1.53-7.02, p=0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also signifcantly lower in the SARS-CoV-2 group, as compared to infuenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88-5.46, p<0.0001). In the whole

Matèries

COVID-19, Unitats de cures intensives, Grip

Matèries (anglès)

COVID-19, Intensive care units, Influenza

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ROUZÉ, Anahita, LEMAITRE, Elise, MARTIN LOECHES, Ignacio, POVOA, Pedro, DIAZ, Emili, NYGA, Rémy, TORRES MARTÍ, Antoni, METZELARD, Matthieu, DU CHEYRON, Damien, LAMBIOTTE, Fabien, TAMION, Fabienne, LABRUYERE, Marie, BOULLE GERONIMI, Claire, LUYT, Charles-edouard, NYUNGA, Martine, POULY, Olivier, THILLE, Arnaud wilfrid, MEGARBANE, Bruno, SAADE, Anastasia, MAGIRA, Eleni, LLITJOS, Jean-françois, IOANNIDOU, Iliana, PIERRE, Alexandre, REIGNIER, Jean, GAROT, Denis, KREITMANN, Louis, BAUDEL, Jean-luc, VOIRIOT, Guillaume, PLANTEFEVE, Gaëtan, MORAWIEC, Elise, ASFAR, Pierre, BOYER, Alexandre, MEKONTSO-DESSAP, Armand, MAKRIS, Demosthenes, VINSONNEAU, Christophe, FLOCH, Pierre-edouard, MAROIS, Clémence, CECCATO, Adrian, ARTIGAS, Antonio, GAUDET, Alexandre. Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study. _Critical Care_. 2022. Vol. 26, núm. 1, pàgs. 11-24. [consulta: 25 de febrer de 2026]. ISSN: 1364-8535. [Disponible a: https://hdl.handle.net/2445/186710]

Exportar metadades

JSON - METS

Compartir registre