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Memory and strategic processing in first-degree relatives of obsessive compulsive patients
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Background: the same executive dysfunctions and alterations in neuroimaging tests (both functional and structural) have been found in obsessive-compulsive patients and their first-degree relatives. These neurobiological findings are considered to be intermediate markers of the disease. The aim of our study was to assess verbal and non-verbal memory in unaffected first-degree relatives, in order to determine whether these neuropsychological functions constitute a new cognitive marker for obsessive-compulsive disorder (OCD). Method: recall and use of organizational strategies in verbal and non-verbal memory tasks were measured in 25 obsessive-compulsive patients, 25 unaffected first-degree relatives and 25 healthy volunteers. Results: first-degree relatives and healthy volunteers did not show differences on most measures of verbal memory. However, during the recall and processing of non-verbal information, deficits were found in first-degree relatives and patients compared with healthy volunteers. Conclusions: the presence of the same deficits in the execution of non-verbal memory tasks in OCD patients and unaffected first-degree relatives suggests the influence of certain genetic and/or familial factors on this cognitive function in OCD and supports the hypothesis that deficits in non-verbal memory tasks could be considered as cognitive markers of the disorder.
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SEGALÀS COSI, Cinto, ALONSO, Pino, REAL, Eva, GARCÍA RUIZ DE GORDEJUELA, Amador, MIÑAMBRES DONAIRE, Aitor, LABAD, Javier, PERTUSA, Alberto, BUENO, Blanca, JIMÉNEZ-MURCIA, Susana, MENCHÓN MAGRIÑÁ, José manuel. Memory and strategic processing in first-degree relatives of obsessive compulsive patients. _Psychological Medicine_. 2010. Vol. 40, núm. 12, pàgs. 2001-2011. [consulta: 8 de gener de 2026]. ISSN: 0033-2917. [Disponible a: https://hdl.handle.net/2445/178238]