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573164.pdf (202.47 KB)

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2008-04-09

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cc-by (c) Menéndez, et al., 2008
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/96004

A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic

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http://dx.doi.org/10.1371/journal.pone.0001934

Resum

Background:Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets(ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of theircombined use.Methods:1030 pregnant Mozambican women of all gravidities received a long-lasting ITN during antenatal clinic (ANC)visits and, irrespective of HIV status, were enrolled in a randomised, double blind, placebo-controlled trial, to assess thesafety and efficacy of 2-dose sulphadoxine-pyrimethamine (SP). The main outcome was the reduction in low birth weight.Findings:Two-dose SP was safe and well tolerated, but was not associated with reductions in anaemia prevalence atdelivery (RR, 0.92 [95% CI, 0.79-1.08]), low birth weight (RR, 0.99 [95% CI, 0.70-1.39]), or overall placental infection(p = 0.964). However, the SP group showed a 40% reduction (95% CI, 7.40-61.20]; p = 0.020) in the incidence of clinicalmalaria during pregnancy, and reductions in the prevalence of peripheral parasitaemia (7.10% vs 15.15%) (p,0.001), and ofactively infected placentas (7.04% vs 13.60%) (p = 0.002). There was a reduction in severe anaemia at delivery of borderlinestatistical significance (p = 0.055). These effects were not modified by gravidity or HIV status. Reported ITN's use was morethan 90% in both groups.Conclusions:Two-dose SP was associated with a reduction in some indicators, but these were not translated to significantimprovement in other maternal or birth outcomes. The use of ITNs during pregnancy may reduce the need to administerIPTp. ITNs should be part of the ANC package in sub-Saharan Africa

Matèries

Embarassades, Malària, Placebos, Assaigs clínics, Àfrica subsahariana

Matèries (anglès)

Pregnant women, Malaria, Placebos (Medicine), Clinical trials, Sub-Saharan Africa

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Articles publicats en revistes (Medicina)

Citació

MENÉNDEZ, Clara, BARDAJÍ, Azucena, SIGAÚQUE, Betuel, ROMAGOSA PÉREZ-PORTABELLA, Cleofé, SANZ, Sergi, SERRA-CASAS, Elisa, MACETE, Eusebio víctor, BERENGUERA, Anna, DAVID, Catarina, DOBAÑO, Carlota, NANICHE, Denise, MAYOR APARICIO, Alfredo gabriel, ORDI I MAJÀ, Jaume, MANDOMANDO, Inácio, APONTE, John j., MABUNDA, Samuel josé alvés, ALONSO, Pedro. A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic. _PLoS One_. 2008. Vol. 3, núm. 4, pàgs. e1934. [consulta: 8 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/96004]

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