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Mol Oncology_Ercilla_2025.pdf (2.29 MB)

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2025-09-15

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cc-by (c) Ercilla Eguiarte, Amaia et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223587

A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer

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Prostate cancer is a prevalent tumor type that, despite being highly curable, progresses to metastatic disease in a fraction of patients, thus accounting for more than 350 000 annual deaths worldwide. In turn, uncovering the molecular insights of metastatic disease is instrumental in improving the survival rate of prostate cancer patients. By means of gene expression meta-analysis in multiple prostate cancer patient cohorts, we identified a set of genes that are differentially expressed in aggressive prostate cancer. Transcription factor 19 (TCF19) stood out as an unprecedented epithelial gene upregulated in metastatic disease, with prognostic potential and negatively associated with the activity of the androgen receptor. By combining computational and empirical approaches, our data revealed that TCF19 is required for full metastatic capacity, and its depletion influences core cancer-related processes, such as tumor growth and vascular permeability, supporting the role of this gene in the dissemination of prostate tumor cells.

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Matèries

Càncer de pròstata, Oncogens

Matèries (anglès)

Prostate cancer, Oncogenes

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

ERCILLA EGUIARTE, Amaia, CRESPO, Jana r., GARCÍA LONGARTE, Saioa, FIDALGO, Marta, PALACIO, Sara del, MARTÍN MARTÍN, Natalia, CARLEVARIS, Onintza, ASTOBIZA, Ianire, FERNÁNDEZ RUIZ, Sonia, GUIU COMADEVALL, Marc, BÁRCENA, Laura, MENDIZABAL, Isabel, ARANSAY, Ana m., GRAUPERA I GARCIA-MILÀ, Mariona, GOMIS I CABRÉ, Roger, CARRACEDO, Arkaitz. A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer. _Molecular oncology_. 2025. [consulta: 25 de novembre de 2025]. ISSN: 1878-0261. [Disponible a: https://hdl.handle.net/2445/223587]

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