Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222714
Advanced antibacterial strategies for combatting biomaterial-associated infections: a comprehensive review
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Resum
Biomaterial-associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These infections significantly risk patient health, resulting in prolonged hospitalization, increased morbidity and mortality rates, and elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion and biofilm formation on biomaterial surfaces, offering an in-depth analysis of current antimicrobial strategies for preventing BAIs. We explore antimicrobial-eluting biomaterials, contact-killing surfaces, and antifouling coatings, emphasizing the application of antifouling polymer brushes on medical devices. Recent advancements in multifunctional antimicrobial biomaterials, which integrate multiple mechanisms for superior protection against BAIs, are also discussed. By evaluating the advantages and limitations of these strategies, this review aims to guide the design and development of highly efficient and biocompatible antimicrobial biomaterials. We highlight potential design routes that facilitate the transition from laboratory research to clinical applications. Additionally, we provide insights into the potential of synthetic biology as a novel approach to combat antimicrobial resistance. This review aspires to inspire future research and innovation, ultimately improving patient outcomes and advancing medical device technology.
Descripció
Matèries (anglès)
Citació
Citació
KASAPGIL, Esra, GARAY SARMIENTO, Manuela, RODRÍGUEZ EMMENEGGER, César. Advanced antibacterial strategies for combatting biomaterial-associated infections: a comprehensive review. _Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology_. 2024. Vol. 16, núm. 6, pàgs. e2018. [consulta: 6 de desembre de 2025]. ISSN: 1939-0041. [Disponible a: https://hdl.handle.net/2445/222714]