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2017-10-16

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cc by (c) Gupta et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/117493

Molecular surveillance of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum isolates from Mozambique

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http://dx.doi.org/10.1186/s12936-017-2061-z

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BACKGROUND: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnostic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. METHODS: Plasmodium falciparum isolates (n = 1162) collected in Southern Mozambique were assessed by RDTs, microscopy and/or 18SrRNA qPCR. pfhrp2 and pfhrp3 deletions were investigated in isolates from individuals who were negative by RDT but positive by microscopy and/or qPCR (n = 69) using gene-specific PCRs, with kelch13 PCR as the parasite DNA control. RESULTS: Lack of pfhrp2 PCR amplification was observed in one of the 69 isolates subjected to molecular analysis [1.45% (95% CI 0.3-7.8%)]. CONCLUSIONS: The low prevalence of pfhrp2 deletions suggests that RDTs will detect the vast majority of the P. falciparum infections. Nevertheless, active surveillance for changing deletion frequencies is required.

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Malària, Moçambic

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Malaria, Mozambique

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GUPTA, Himanshu, MATAMBISSO, Gloria, GALATAS, Beatriz, CISTERÓ, Pau, NHAMUSSUA, Lidia, SIMONE, Wilson, CUNNINGHAM, Jane, RABINOVICH, Regina, ALONSO, Pedro, SAUTE, Francisco, AIDE, Pedro carlos paulino, MAYOR APARICIO, Alfredo gabriel. Molecular surveillance of pfhrp2 and pfhrp3 deletions in
                Plasmodium falciparum isolates from Mozambique. _Malaria Journal_. 2017. Vol. 16, núm. 1, pàgs. 416. [consulta: 29 de gener de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/117493]

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