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2015-07-11

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cc by (c) Ramón y Cajal et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126646

Mammographic density and breast cancer in women from high risk families

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https://doi.org/10.1186/s13058-015-0604-1

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Introduction: Mammographic density (MD) is one of the strongest determinants of sporadic breast cancer (BC). In this study, we compared MD in BRCA1/2 mutation carriers and non-carriers from BRCA1/2 mutation-positive families and investigated the association between MD and BC among BRCA1/2 mutation carriers per type of mutation and tumor subtype. Methods: The study was carried out in 1039 female members of BRCA1 and BRCA2 mutation-positive families followed at 16 Spanish Genetic Counseling Units. Participants' density was scored retrospectively from available mammograms by a single blinded radiologist using a 5-category scale (<10 %, 10-25 %, 25-50 %, 50-75 %, >75 %). In BC cases, we selected mammograms taken prior to diagnosis or from the contralateral breast, whereas, in non-cases, the last screening mammogram was evaluated. MD distribution in carriers and non-carriers was compared using ordinal logistic models, and the association between MD and BC in BRCA1/2 mutation carriers was studied using logistic regression. Huber-White robust estimators of variance were used to take into account correlations between family members. A similar multinomial model was used to explore this association by BC subtype. Results: We identified and scored mammograms from 341 BRCA1, 350 BRCA2 mutation carriers and 229 non-carriers. Compared to non-carriers, MD was significantly lower among BRCA2 mutation carriers (odds ratio (OR) =0.71; P-value=0.04), but not among BRCA1 carriers (OR=0.84; P-value=0.33). MD was associated with subsequent development BC (OR per category of MD=1.45; 95 % confidence interval=1.18-1.78, P-value<0.001), with no significant differences between BRCA1 and BRCA2 mutation carriers (P-value=0.48). Finally, no statistically significant differences were observed in the association of MD with specific BC subtypes. Conclusions: Our study, the largest to date on this issue, confirms that MD is an independent risk factor for all BC subtypes in either BRCA1 and BRCA2 mutation carriers, and should be considered a phenotype risk marker in this context.

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Càncer de mama

Matèries (anglès)

Breast cancer

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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RAMÓN Y CAJAL, Teresa, CHIRIVELLA GONZÁLEZ, Isabel, MIRANDA, Josefa, TEULÉ-VEGA, Àlex, IZQUIERDO I FONT, Àngel xavier, BALMAÑA, Judith, SÁNCHEZ HERAS, Ana beatriz, LLORT PURSALS, Gemma, FISAS, David, LOPE, Virginia, HERNÁNDEZ AGUDO, Elena, JUAN FITA, María josé, TENA, Isabel, ROBLES, Luis, GUILLÉN PONCE, Carmen, PÉREZ SEGURA, Pedro, LUQUE MOLINA, Mari sol, HERNANDO POLO, Susana, SALINAS MASDEU, Mònica, BRUNET, Joan, SALAS TREJO, María dolores, BARNADAS, Agustí, POLLÁN, Marina. Mammographic density and breast cancer in women from high risk families. _Breast Cancer Research_. 2015. Vol. 17, núm. 93. [consulta: 9 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126646]

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