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912072.pdf (1.31 MB)

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2025-11-14

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cc-by-nc-nd (c) Fuertes, Irene et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227470

A cross-sectional pilot study to define anal cancer risk factors in HIV-positive solid organ transplant recipients.

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Recurs relacionat

https://doi.org/10.1080/23744235.2025.2573412

Resum

Background HIV-positive organ transplant recipients are at high risk of anal cancer, but there are no data on the prevalence of high-risk human papillomavirus (hr-HPV) or anal dysplasia, in this population. Objective To assess the prevalence of anal hr-HPV, and anal cytological and histological abnormalities in this population. Design and setting Prospective single tertiary hospital. Results Twenty-five (53%) transplant recipients were recruited from 47 eligible individuals. Median (IQR) age was 56 years (52.5–60), 17 were male, 9 (36%) were men who have sex with men and 8 (32%) were active smokers. Twelve (48%) patients had abnormal anal cytology and 12 (48%) had detectable hr-HPV DNA. Six (50%) individuals with abnormal cytology had high-grade squamous intraepithelial lesions (HSIL) on biopsy. Abnormal anal cytology was significantly associated with current hr-HPV infection [crude prevalence rate ratio, cRR = 2.3, 95% CI (1.43–3.7); p = 0.001] and any previous history of HPV associated disease [cRR = 2.49, 95% CI (1.09–5.67); p = 0.030]. Anal HSIL on biopsy was associated with presence of condyloma [cRR = 3.00, 95% CI (1.31–6.88); p = 0.001] and any previous history of any HPV associated disease [cRR = 6.67, 95% CI (0.96–46.32); p = 0.055]. Anal hr-HPV infection was associated with any previous HPV disease (Crude risk ratios [cRR = 2.89, 95% CI (1.21–6.88); p = 0.017]) and presence of condyloma (Crude risk ratios [cRR = 2.00, 95% CI (1.28–3.13); p = 0.002]). No cases of invasive anal cancer were detected among study participants. Conclusions This highly medicalized population of HIV-positive organ transplant recipients have a high prevalence of HPV-associated anal dysplasia and screening to prevent anal cancer may need to be prioritised.

Matèries

Trasplantament d'òrgans, Papil·lomavirus, VIH (Virus)

Matèries (anglès)

Transplantation of organs, Papillomaviruses, HIV (Viruses)

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)

Citació

FUERTES, Irene, et al. A cross-sectional pilot study to define anal cancer risk factors in HIV-positive solid organ transplant recipients. Infectious Diseases. 2025. ISSN 2374-4235. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/227470

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