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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/155477
Potential role of aminoprocalcitonin in the pathogenesis of alzheimer disease
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Increasing evidence suggests that inflammatory responses cause brain atrophy and play a prominent and early role in the progression of Alzheimer disease. Recent findings show that the neuroendocrine peptide aminoprocalcitonin (NPCT) plays a critical role in the development of systemic inflammatory response; however, the presence, possible function, regulation, and mechanisms by which NPCT may be involved in Alzheimer disease neuropathology remain unknown. We explored the expression of NPCT and its interaction with amyloid-b (Ab), and proinflammatory and neurogenic effects. By using brain samples of Alzheimer disease patients and APP/PS1 transgenic mice, we evaluated the potential role of NPCT on Ab-related pathology. We found that NPCT is expressed in hippocampal and cortical neurons and Ab-induced up-regulation of NPCT expression. Peripherally administered antibodies against NPCT decreased microglial activation, decreased circulating levels of proinflammatory cytokines, and prevented Ab-induced neurotoxicity in experimental models of Alzheimer disease. Remarkably, anti-NPTC therapy resulted in a significant improvement in the behavioral status of APP/PS1 mice. Our results indicate a central role of NPCT in Alzheimer disease pathogenesis and suggest NPCT as a potential biomarker and therapeutic target.
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TAVARES, Eva, ANTEQUERA, Desiree, LÓPEZ GONZÁLEZ, Irene, FERRER, Isidro (ferrer abizanda), MIÑANO, Francisco j., CARRO, Eva. Potential role of aminoprocalcitonin in the pathogenesis of alzheimer disease. _American Journal of Pathology_. 2016. Vol. 186, núm. 10, pàgs. 2723-2735. [consulta: 20 de gener de 2026]. ISSN: 0002-9440. [Disponible a: https://hdl.handle.net/2445/155477]