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2016-12

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cc-by-nc-nd (c) Sociedade Portuguesa de Cardiologia , 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/114645

Does anemia affect the predictive ability of bleeding risk scores in patients with acute coronary syndromes?

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Recurs relacionat

https://doi.org/10.1016/j.repc.2016.06.011

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Introduction and objective: Anemia is a common comorbidity in patients with acute coronary syndromes (ACS), and is associated with higher risk for both bleeding and ischemic complications. We aimed to assess the predictive ability of bleeding risk scores (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines [CRUSADE], Mehran and Acute Coronary Treatment and Intervention Outcomes Network [ACTION]) in ACS patients with anemia. Methods: All consecutive ACS patients were prospectively included. The primary outcome was in-hospital major bleeding according to the CRUSADE, Mehran and ACTION definitions. Anemia was defined as hemoglobin <130 g/l in men and <120 g/l in women. The predictive ability of the bleeding risk scores was assessed by binary logistic regression, calculating receiver operating characteristic (ROC) curves and their corresponding area under the curve (AUC). Results: We included 2255 patients, mean age 62.4 years. Anemia was present in 550 patients (24.4%). Patients with anemia had a significantly higher prevalence of comorbidities. The three bleeding risk scores adequately predicted major bleeding in the whole cohort. No significant differences were observed regarding the predictive ability of each of the scores in patients with and without anemia (CRUSADE: AUC 0.73 without anemia vs. 0.74 with anemia, p=0.913; ACTION: AUC 0.68 without anemia vs. 0.73 with anemia, p=0.353; Mehran: AUC 0.69 without anemia vs. 0.61 with anemia, p=0.210). Only the Mehran score showed significantly lower predictive ability in patients with hemoglobin <11 g/dl (AUC 0.51, p=0.044). Conclusions: Anemia was a common comorbidity in patients with ACS from our series. Currently available bleeding risk scores showed an adequate predictive ability in patients with mild anemia.

Matèries

Anèmia, Hemorràgia, Malalties coronàries, Comorbiditat, Factors de risc en les malalties

Matèries (anglès)

Anemia, Hemorrhage, Coronary diseases, Comorbidity, Risk factors in diseases

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Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GARAY, Alberto, ARIZA SOLÉ, Albert, FORMIGA PÉREZ, Francesc, LORENTE, Victòria, SÁNCHEZ-SALADO, José c., SALAZAR-MENDIGUCHÍA, Joel, ROURA I FERRER, Gerard, MUNTANÉ, Guillem, ALEGRE CANALS, Oriol, FUENTES, Lara, GÓMEZ HOSPITAL, Joan antoni, CEQUIER FILLAT, Àngel r.. Does anemia affect the predictive ability of bleeding risk scores in patients with acute coronary syndromes?. _Revista Portuguesa de Cardiologia_. 2016. Vol. 35, núm. 12, pàgs. 637-644. [consulta: 21 de gener de 2026]. ISSN: 0870-2551. [Disponible a: https://hdl.handle.net/2445/114645]

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