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Galectin-3 is upregulated in frontotemporal dementia patients.pdf (740.8 KB)

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2024-03-01

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cc by-nc-nd (c) Borrego Écija, Sergi et al, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/214353

Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity

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https://doi.org/10.1002/alz.13536

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INTRODUCTIONNeuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential.METHODSWe examined Gal-3 levels in brain, serum, and cerebrospinal fluid (CSF) samples of patients with FTD and controls. Multiple linear regressions between Gal-3 levels and other FTD markers were explored.RESULTSGal-3 levels were increased significantly in patients with FTD, mainly across brain tissue and CSF, compared to controls. Remarkably, Gal-3 levels were higher in cases with tau pathology than TAR-DNA Binding Protein 43 (TDP-43) pathology. Only MAPT mutation carriers displayed increased Gal-3 levels in CSF samples, which correlated with total tau and 14-3-3.DISCUSSIONOur findings underscore the potential of Gal-3 as a diagnostic marker for FTD, particularly in MAPT cases, and highlights the relation of Gal-3 with neuronal injury markers.

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BORREGO ÉCIJA, Sergi, et al. Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity. Alzheimers & Dementia. 2024. Vol. 20, num. 3, pags. 1515-1526. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/214353

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