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Galectin-3 is upregulated in frontotemporal dementia patients.pdf (740.8 KB)

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2024-03-01

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cc by-nc-nd (c) Borrego Écija, Sergi et al, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/214353

Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity

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https://doi.org/10.1002/alz.13536

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INTRODUCTIONNeuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential.METHODSWe examined Gal-3 levels in brain, serum, and cerebrospinal fluid (CSF) samples of patients with FTD and controls. Multiple linear regressions between Gal-3 levels and other FTD markers were explored.RESULTSGal-3 levels were increased significantly in patients with FTD, mainly across brain tissue and CSF, compared to controls. Remarkably, Gal-3 levels were higher in cases with tau pathology than TAR-DNA Binding Protein 43 (TDP-43) pathology. Only MAPT mutation carriers displayed increased Gal-3 levels in CSF samples, which correlated with total tau and 14-3-3.DISCUSSIONOur findings underscore the potential of Gal-3 as a diagnostic marker for FTD, particularly in MAPT cases, and highlights the relation of Gal-3 with neuronal injury markers.

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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BORREGO ÉCIJA, Sergi, PÉREZ MILLAN, Agnès, ANTONELL BOIXADER, Anna, FORT AZNAR, Laura, KAYA TILKI, E., LEÓN HALCON, A., LLADÓ PLARRUMANÍ, Albert, MOLINA PORCEL, Laura, BALASA, Mircea, JUNCÒ PARELLA, J., VITORICA, J., VENERO, J. l., DEIERBORG, T., BOZA SERRANO, A., SÁNCHEZ DEL VALLE DÍAZ, Raquel. Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity. _Alzheimers & Dementia_. 2024. Vol. 20, núm. 3, pàgs. 1515-1526. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/214353]

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