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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/110393
Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism
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The dicyclohexylborane-mediated addition of allene 1 to (E)-2-tridecenal affords a quaternary protected 2-amino-2-vinyl-1,3-diol in good yield as a single diastereomer. This compound is readily transformed into the four stereoisomers of the quaternary (E)-2-vinyl analogs of sphingosine. The metabolic fate and the effect of these compounds on the basal sphingolipid metabolism in human A549 lung adenocarcinoma cells has been studied, together with the ceramide analog of the most relevant vinylsphingosine derivative.
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CALDERÓN I ALMENDRO, Raquel, et al. Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism. Chemistry and Physics of Lipids. 2017. Vol. 205, num. 34-41. ISSN 0009-3084. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/110393