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2024-01-01

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cc-by-nc-nd (c) Elsevier, 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/217188

Eficacia y seguridad de un compuesto de ácidos grasos hiperoxigenados en la mejora de la microcirculación de la púrpura fulminante en pacientes pediátricos con sepsis: estudio piloto

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https://doi.org/10.1016/j.enfi.2023.04.003

Abstract

Introduction: Purpura fulminans (PF) is a serious complication of sepsis resulting from a set of alterations characterised by the development of ecchymotic haemorrhagic lesions and skin necrosis. Aim: To analyse the efficacy and safety of the topical application of HOFA compound, in the cutaneous microcirculation of PF lesions in paediatric patients affected by sepsis. Material and methods: A prospective quasi-experimental pre-test/post-test single-group conducted in a Paediatric Intensive Care Unit of a third level hospital was performed. Paediatric patients aged 0-18 years with sepsis were included. Somatic oximetry values were measured before and after application of HOFAs every 4h over the first three days of the patients' hospitalisation. Patient's socio-demographic and clinical variables and somatic oximetry by placing a sensor for measuring tissue perfusion on the area with PF were determined. Results: Four patients were recruited, with a median age of 98 months. The purpuric lesions measured were mainly located on both feet and hands and, in two patients, also on the lateral malleoli and calves of both lower extremities. A total of 225 measurements were obtained, with mean pre-intervention scores of 71.17±15.65% versus 73.68±14.83% post-intervention. Statistical significance (p<0.001) was observed upon comparison of the pre- and post-intervention measurements. Conclusions: Early and continued application of HOFAs in the management of sepsis-induced PF is an effective and safe practice in the cases analysed. In more than half of the episodes analysed, an increase in tissue microcirculation was observed after the application of HOFAs, with no adverse events.

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Unitats de cures intensives, Malalties infeccioses, Xoc sèptic, Malalties dels infants, Trastorns de la coagulació sanguínia

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Intensive care units, Communicable diseases, Septic shock, Children's diseases, Blood coagulation disorders

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Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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PÉREZ ACEVEDO, Gemma, BOSCH ALCARAZ, Alejandro and TORRA I BOU, Joan-Enric. Eficacia y seguridad de un compuesto de ácidos grasos hiperoxigenados en la mejora de la microcirculación de la púrpura fulminante en pacientes pediátricos con sepsis: estudio piloto. Enfermeria Intensiva. 2024. Vol. 35, num. 1, pags. 13-22. ISSN 1130-2399. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/217188

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