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2018-03-12

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cc-by (c) Dierssen Sotos, Trinidad et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/137201

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

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https://doi.org/10.1186/s12885-018-4182-3

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BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.

Matèries

Càncer de mama, Reproducció humana, Genètica

Matèries (anglès)

Breast cancer, Human reproduction, Genetics

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

Citació

DIERSSEN SOTOS, Trinidad, PALAZUELOS-CALDERÓN, Camilo, JIMÉNEZ MOLEÓN, José juan, ARAGONÈS SANZ, Núria, ALTZIBAR, Jone m., CASTAÑO-VINYALS, Gemma, MARTÍN SÁNCHEZ, Vicente, GÓMEZ ACEBO, Inés, GUEVARA, Marcela, TARDÓN, Adonina, PÉREZ GÓMEZ, Beatriz, AMIANO, Pilar, MORENO AGUADO, Víctor, MOLINA DE LA TORRE, Antonio josé, ALONSO MOLERO, Jéssica, MORENO IRIBAS, Conchi, KOGEVINAS, Manolis, POLLÁN, Marina, LLORCA DÍAZ, Javier. Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project. _BMC Cancer_. 2018. Vol. 18, núm. 280. [consulta: 25 de gener de 2026]. ISSN: 1471-2407. [Disponible a: https://hdl.handle.net/2445/137201]

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