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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/125673
Purinergic Signalling in Immune System Regulation in Health and Disease
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The concept of a purinergic signalling system was first proposed by Professor Geoffrey Burnstock over 30 years ago. This includes the cellular responses to purine nucleotides, such as ATP, and nucleosides, such as adenosine, that act as extracellular messengers playing a role through specific nucleotide and adenosine receptors in all systems. Indeed, in addition to their role in cellular metabolism, nucleotides as well as nucleosides are extracellular mediators that activate biological responses in all cells. Cells subjected to activation or shear or mechanical stress release nucleotides such as ATP, ADP, UTP, and UDP in large amounts. All cells can release nucleotides in a controlled fashion [1]. The mechanisms of nucleotide release have been the focus of intense research activities but are still not fully understood. While activated platelets and neurons release nucleotides by exocytosis, neutrophils, and T lymphocytes use pannexin-1 hemichannels for nucleotide efflux, some cells also constitutively release nucleotides.
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SÉVIGNY, Jean, MARTÍN SATUÉ, Mireia and PINTOR, Jesús J. Purinergic Signalling in Immune System Regulation in Health and Disease. Mediators of Inflammation. 2015. Vol. 2015 Article ID. ISSN 0962-9351. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/125673