Miniatura

Fitxers

Changes in Circulating Metabolites During Weight Loss are Associated with Adiposity Improvement, and Body Weight and Adiposity Regain During Weight Loss Maintenance_ The SATIN Study.pdf (620.31 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-07-21

Llicència de publicació

cc by (c) Papandreou, Christopher et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179805

Changes in Circulating Metabolites During Weight Loss are Associated with Adiposity Improvement, and Body Weight and Adiposity Regain During Weight Loss Maintenance: The SATIN Study

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1002/mnfr.202001154

Resum

Scope: To examine the relationship between changes in circulating metabolites during diet-induced weight loss and changes of adiposity. This study also investigates changes in these metabolites in relation to body weight and adiposity regain during a weight loss maintenance period. Methods and results: This cohort study is nested within the Satiety Innovation (SATIN) study. Participants (n = 162) achieving ≥8% weight loss during an initial 8-week low-calorie formula diet (LCD) are included in a 12-week weight loss maintenance period. A targeted metabolite profiling (123 metabolites) approach is applied using three different platforms (proton nuclear magnetic resonance, liquid chromatography mass spectrometry, gas chromatography mass spectrometry). Changes in several lipid species and citric acid are significantly associated with greater reduction of body weight, total fat, and abdominal adiposity distribution during the LCD. Decreases in the concentrations of lysophosphatidylcholines (LPCs) 14:0, LPC 20:3, phosphatidylcholine (PC) 32:2, PC 38:3, sphingomyelin (SM) 32:2, and increases in citric acid concentrations during the LCD are associated with adiposity regain and loss, respectively, during the weight loss maintenance period. Conclusions: The results show that weight loss is associated with changes in lipid species and citric acid. These changes are related to subsequent weight and adiposity regain identifying the adipose lipid metabolism as an important factor for the maintenance of lost weight and adiposity. Keywords: SATIN; metabolomics; weight loss; weight maintenance.

Matèries

Metabolisme dels lípids, Pes corporal, Obesitat

Matèries (anglès)

Lipid metabolism, Body weight, Obesity

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

PAPANDREOU, Christopher, GARCÍA GAVILÁN, Jesús, CAMACHO BARCIA, Lucía, TOFT HANSEN, Thea, HARROLD, Joanne a., SJÖDIN, Anders, HALFORD, Jason c. g., BULLÓ, Mònica. Changes in Circulating Metabolites During Weight Loss are Associated with Adiposity Improvement, and Body Weight and Adiposity Regain During Weight Loss Maintenance: The SATIN Study. _Molecular Nutrition & Food Research_. 2021. Vol. 65, núm. num 17, pàgs. 2001154. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/179805]

Exportar metadades

JSON - METS

Compartir registre