Miniatura

Fitxers

PIIS1201971216309985.pdf (266.94 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2016-05

Llicència de publicació

cc by-nc-nd (c) Winter et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/98687

Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1016/j.ijid.2016.03.011

Resum

OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS: Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/mul. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS: No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.

Matèries

VIH (Virus), Virus de l'hepatitis delta

Matèries (anglès)

HIV (Viruses), Hepatitis D (hepatitis delta)

Citació

Col·leccions

Articles publicats en revistes (ISGlobal)

Citació

WINTER, Annja, LETANG, Emilio, KALINJUMA, Aneth vedastus, KIMERA, Namvua, NTAMATUNGIRO, Alex j., GLASS, Tracy r., MORADPOUR, Darius, SAHLI, Roland, LE GAL, Frédéric, FURRER, Hansjakob, WANDELER, Gilles, KIULARCO Study Group. Absence of hepatitis delta infection in a large rural HIV cohort
                in Tanzania. _International Journal of Infectious Diseases_. 2016. Vol. 46, núm. 8-10. [consulta: 23 de gener de 2026]. ISSN: 1201-9712. [Disponible a: https://hdl.handle.net/2445/98687]

Exportar metadades

JSON - METS

Compartir registre