Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/120091
TGFβ controls ovarian cancer cell proliferation
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the signaling pathways involved is required. The Transforming Growth Factor (TGFβ) family controls different cellular responses in development and cell homeostasis. Disruption of TGFβ signaling has been implicated in many cancers, including ovarian cancer. This article considers the involvement of TGFβ in ovarian cancer progression, and reviews the various mechanisms that enable the TGFβ signaling pathway to control ovarian cancer cell proliferation. These mechanistic explanations support the therapeutic use of TGFβ inhibitors in ovarian cancer, which are currently in the early phases of development.
Subject (English)
Citation
Citation
ALSINA SANCHÍS, Elisenda, et al. TGFβ controls ovarian cancer cell proliferation. International Journal of Molecular Sciences. 2017. Vol. 18, num. 8, pags. 1658. ISSN 1661-6596. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/120091