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s41375-021-01302-5.pdf (1.07 MB)

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2021-06-02

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cc by (c) Ljungman et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178231

COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey

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https://doi.org/10.1038/s41375-021-01302-5

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This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (-0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.

Matèries

COVID-19, Mortalitat, Cèl·lules mare

Matèries (anglès)

COVID-19, Mortality, Stem cells

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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LJUNGMAN, Per, CAMARA, Rafael de la, MIKULSKA, Malgorzata, TRIDELLO, Gloria, AGUADO, Beatriz, ZAHRANI, Mohsen al, APPERLEY, Jane, BERCEANU, Ana, MARTINO BOFARULL, Rodrigo, CALBACHO, María, CICERI, Fabio, LÓPEZ CORRAL, Lucía, CRIPPA, Claudia, FOX, Maria laura, GRASSI, Anna, JIMENEZ, Maria jose, DEMIR, Safiye koçulu, KWON, Mi, LLAMAS, Carlos vallejo, LÓPEZ LORENZO, José luis, MIELKE, Stephan, ORCHARD, Kim, PARODY, Rocío, VALLISA, Daniele, XHAARD, Alienor, KNELANGE, Nina simone, CEDILLO, Angel, KRÖGER, Nicolaus, PIÑANA, José luis, STYCZYNSKI, Jan. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey. _Leukemia_. 2021. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/178231]

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