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Synthetic applications of chiral unsaturated epoxy alcohols prepared by sharpless asymmetric epoxidation
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An overview of the synthesis and applications of chiral 2,3-epoxy alcohols containing unsaturated chains is presented. One of the fundamental synthetic routes to these compounds is Sharpless asymmetric epoxidation, which is reliable, highly chemoselective and enables easy prediction of the product enantioselectivity. Thus, unsaturated epoxy alcohols are readily obtained by selective oxidation of the allylic double bond in the presence of other carbon-carbon double or triple bonds. The wide availability of epoxy alcohols with unsaturated chains, the versatility of the epoxy alcohol functionality (e.g. regio- and stereo-selective ring opening; oxidation; and reduction), and the arsenal of established alkene chemistries, make unsaturated epoxy alcohols powerful starting materials for the synthesis of complex targets such as biologically active molecules. The popularization of ring-closing metathesis has further increased their value, making them excellent precursors to cyclic compounds.
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RIERA I ESCALÉ, Antoni and MORENO, María. Synthetic applications of chiral unsaturated epoxy alcohols prepared by sharpless asymmetric epoxidation. Molecules 2010. 15(2). Vol. 1041-1073. ISSN 1420-3049. [consulted: 26 of May of 2026]. Available at: https://hdl.handle.net/2445/20788