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Hippocampal abnormalities and age in chronic schizophrenia: morphometric study across the adult lifespan
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Background: Hippocampal abnormalities have been demonstrated in schizophrenia. It is unclear whether these abnormalities worsen with age, and whether they affect cognition and function.
Aims: To determine whether hippocampal abnormalities in chronic schizophrenia are associated with age, cognition and socio-occupational function.
Method: Using 3 T magnetic resonance imaging we scanned 100 persons aged 19-82 years: 51 were out-patients with stable schizophrenia at least 2 years after diagnosis and 49 were healthy volunteers matched for age and gender. Automated analysis was used to determine hippocampal volume and shape.
Results: There were differential effects of age in the schizophrenia and control samples on total hippocampal volume (group × age interaction: F(1,95) = 6.57, P = 0.012), with steeper age-related reduction in the schizophrenia group. Three-dimensional shape analysis located the age-related deformations predominantly in the mid-body of the hippocampus. In the schizophrenia group similar patterns of morphometric abnormalities were correlated with impaired cognition and poorer socio-occupational function.
Conclusions: Hippocampal abnormalities are associated with age in people with chronic schizophrenia, with a steeper decline than in healthy individuals. These abnormalities are associated with cognitive and functional deficits, suggesting that hippocampal morphometry may be a biomarker for cognitive decline in older patients with schizophrenia.
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PUJOL, Núria, PENADÉS RUBIO, Rafael, JUNQUÉ I PLAJA, Carme, DINOV, Ivo, FU, Cynthia h. y., CATALÁN CAMPOS, Rosa, IBARRETXE BILBAO, Naroa, BARGALLÓ ALABART, Núria, BERNARDO ARROYO, Miquel, TOGA, Arthur, HOWARD, Robert j., COSTAFREDA, Sergi g.. Hippocampal abnormalities and age in chronic schizophrenia: morphometric study across the adult lifespan. _British Journal of Psychiatry_. 2014. Vol. 205, núm. 5, pàgs. 369-375. [consulta: 6 de febrer de 2026]. ISSN: 0007-1250. [Disponible a: https://hdl.handle.net/2445/226480]