Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Fitxers

177452.pdf (694.81 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2014-09-11

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226480

Hippocampal abnormalities and age in chronic schizophrenia: morphometric study across the adult lifespan

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1192/bjp.bp.113.140384

Resum

Background: Hippocampal abnormalities have been demonstrated in schizophrenia. It is unclear whether these abnormalities worsen with age, and whether they affect cognition and function. Aims: To determine whether hippocampal abnormalities in chronic schizophrenia are associated with age, cognition and socio-occupational function. Method: Using 3 T magnetic resonance imaging we scanned 100 persons aged 19-82 years: 51 were out-patients with stable schizophrenia at least 2 years after diagnosis and 49 were healthy volunteers matched for age and gender. Automated analysis was used to determine hippocampal volume and shape. Results: There were differential effects of age in the schizophrenia and control samples on total hippocampal volume (group × age interaction: F(1,95) = 6.57, P = 0.012), with steeper age-related reduction in the schizophrenia group. Three-dimensional shape analysis located the age-related deformations predominantly in the mid-body of the hippocampus. In the schizophrenia group similar patterns of morphometric abnormalities were correlated with impaired cognition and poorer socio-occupational function. Conclusions: Hippocampal abnormalities are associated with age in people with chronic schizophrenia, with a steeper decline than in healthy individuals. These abnormalities are associated with cognitive and functional deficits, suggesting that hippocampal morphometry may be a biomarker for cognitive decline in older patients with schizophrenia.

Matèries

Hipocamp (Cervell), Esquizofrènia

Matèries (anglès)

Hippocampus (Brain), Schizophrenia

Citació

Col·leccions

Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PUJOL, Núria, et al. Hippocampal abnormalities and age in chronic schizophrenia: morphometric study across the adult lifespan. British Journal of Psychiatry. 2014. Vol. 205, num. 5, pags. 369-375. ISSN 0007-1250. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/226480

Exportar metadades

JSON - METS

Compartir registre