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1-s2.0-S0753332222007855-main.pdf (8.81 MB)

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2022-09-01

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cc by-nc-nd (c) Bińkowski, Jan et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/188912

Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection

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Recurs relacionat

https://doi.org/10.1016/j.biopha.2022.113396

Resum

Recent studies have shown that methylation changes identified in blood cells of COVID-19 patients have a po-tential to be used as biomarkers of SARS-CoV-2 infection outcomes. However, different studies have reported different subsets of epigenetic lesions that stratify patients according to the severity of infection symptoms, and more importantly, the significance of those epigenetic changes in the pathology of the infection is still not clear. We used methylomics and transcriptomics data from the largest so far cohort of COVID-19 patients from four geographically distant populations, to identify casual interactions of blood cells' methylome in pathology of the COVID-19 disease. We identified a subset of methylation changes that is uniformly present in all COVID-19 patients regardless of symptoms. Those changes are not present in patients suffering from upper respiratory tract infections with symptoms similar to COVID-19. Most importantly, the identified epigenetic changes affect the expression of genes involved in interferon response pathways and the expression of those genes differs be-tween patients admitted to intensive care units and only hospitalized. In conclusion, the DNA methylation changes involved in pathophysiology of SARS-CoV-2 infection, which are specific to COVID-19 patients, can not only be utilized as biomarkers in the disease management but also present a potential treatment target.

Matèries

COVID-19, Epigenètica

Matèries (anglès)

COVID-19, Epigenetics

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BIŃKOWSKI, Jan, et al. Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection. Biomedicine & Pharmacotherapy. 2022. Vol. 153, num. 113396. ISSN 1950-6007. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/188912

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