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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/118592
Combating virulence of Gram-negative bacilli by OmpA inhibition
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Abstract
Preventing the adhesion of pathogens to host cells provides an
innovative approach to tackling multidrug-resistant bacteria. In
this regard, the identification of outer membrane protein A
(OmpA) as a key bacterial virulence factor has been a major
breakthrough. The use of virtual screening helped us to identify
a cyclic hexapeptide AOA-2 that inhibits the adhesion of
Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia
coli to host cells and the formation of biofilm, thereby
preventing the development of infection in vitro and in a murine
sepsis peritoneal model. Inhibition of OmpA offers a strategy as
monotherapy to address the urgent need for treatments for
infections caused by Gram-negative bacilli.
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VILA FARRÉS, Xavier, et al. Combating virulence of Gram-negative bacilli by OmpA inhibition. Scientific Reports. 2017. Vol. 7, num. 1, pags. 14683. ISSN 2045-2322. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/118592