Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/191102
Using pluripotent stem cells to understand normal and leukemic hematopoietic development
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Several decades have passed since the generation of the first embryonic stem cell (ESC) lines both in mice and in humans. Since then, stem cell biologists have tried to understand their potential biological and clinical uses for their implementation in regenerative medicine. The hematopoietic field was a pioneer in establishing the potential use for the development of blood cell products and clinical applications; however, early expectations have been truncated by the difficulty in generating bonafide hematopoietic stem cells (HSCs). Despite some progress in understanding the origin of HSCs during embryonic development, the reproduction of this process in vitro is still not possible, but the knowledge acquired in the embryo is slowly being implemented for mouse and human pluripotent stem cells (PSCs). In contrast, ESC-derived hematopoietic cells may recapitulate some leukemic transformation processes when exposed to oncogenic drivers. This would be especially useful to model prenatal leukemia development or other leukemia-predisposing syndromes, which are difficult to study. In this review, we will review the state of the art of the use of PSCs as a model for hematopoietic and leukemia development.
Matèries (anglès)
Citació
Citació
BIGAS SALVANS, Anna, GALÁN PALMA, Luis, KARTHA, Gayathri m., GIORGETTI, Alessandra. Using pluripotent stem cells to understand normal and leukemic hematopoietic development. _Stem Cells Translational Medicine_. 2022. Vol. 11, núm. 11, pàgs. 1123-1134. [consulta: 20 de gener de 2026]. ISSN: 2157-6564. [Disponible a: https://hdl.handle.net/2445/191102]