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2025-12-01

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cc-by (c) Jiménez-Peinado, A. et al., 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219976

Respiratory disease in people with Major Depressive Disorder: A Systematic Review and Meta-analysis

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https://doi.org/10.1192/j.eurpsy.2025.13

Abstract

Background: Living with major depressive disorder (MDD) reduces life expectancy, with respiratory disease being a significant threat. However, evidence on respiratory disease in this population has not yet been meta-analyzed. Methods: This meta-analysis examines respiratory disease prevalence and odds ratio (OR) in patients with MDD and treatment resistant depression (TRD). A systematic literature search was conducted, with a snowball search of reference and citation lists. Inclusion criteria covered studies in MDD and TRD patients with confirmed diagnoses of respiratory diseases (asthma, chronic obstructive pulmonary disease [COPD], pneumonia, lung cancer, and tuberculosis), comparing with a control group when possible. Results: From 4,138 retrieved articles, 15 (including 476,927 individuals with MDD, 50,680 with TRD, and 1,108,979 control group) met the inclusion criteria. In MDD patients, COPD prevalence was 9.0% (95% CI: 3.8-19.6%), asthma 8.6% (95% CI: 5.7-12.8%), and pneumonia 2.5% (95% CI: 2.2-2.9%). In TRD patients, COPD prevalence was 9.9% (95% CI: 4.2-21.9%) and asthma 10.9% (95% CI: 10.7-11.2%), but meta-analysis limited to those diseases showed no significant relative risk differences. Compared to the general population, individuals with MDD had significantly higher rates of COPD (OR 1.79, 95% CI: 1.49-2.16), even higher in younger populations (1.85 [95% CI: 1.74-1.97]) and more prevalent in women. Conclusions: This first meta-analysis on this topic shows that MDD is associated with an increased risk of respiratory illness compared to the general population. The prevalence of asthma doubles the mean described in the general population worldwide, and in COPD, women and younger people are at particular risk. Prevention policies are urgently needed.

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Malalties pulmonars obstructives cròniques, Depressió psíquica, Asma, Esperança de vida

Subject (English)

Chronic obstructive pulmonary diseases, Mental depression, Asthma, Life expectancy

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citation

JIMÉNEZ PEINADO, Ana, et al. Respiratory disease in people with Major Depressive Disorder: A Systematic Review and Meta-analysis. European Psychiatry. 2025. Vol. 68, num. 1. ISSN 0924-9338. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/219976

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