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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176018
Lower Locus Coeruleus MRI intensity in patients with late-life major depression
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Background: The locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may increase to a variable extent the likelihood of developing neurodegenerative conditions. The characterization of such alterations may therefore help to predict progression to neurodegenerative disorders. Despite the LC cannot be visualized with conventional magnetic resonance imaging (MRI), specific MRI sequences have been developed to infer its structural integrity. Methods: We quantified LC signal Contrast Ratios (LCCRs) in late-life major depressive disorder (MDD) (n = 37, 9 with comorbid aMCI), amnestic Mild Cognitive Impairment (aMCI) (n = 21, without comorbid MDD), and healthy controls (HCs) (n = 31), and also assessed the putative modulatory effects of comorbidities and other clinical variables. Results: LCCRs were lower in MDD compared to aMCI and HCs. While no effects of aMCI comorbidity were observed, lower LCCRs were specifically observed in patients taking serotonin/norepinephrine reuptake inhibitors (SNRIs). Conclusion: Our results do not support the hypothesis that lower LCCRs characterize the different clinical groups that may eventually develop a neurodegenerative disorder. Conversely, our results were specifically observed in patients with late-life MDD taking SNRIs. Further research with larger samples is warranted to ascertain whether medication or particular clinical features of patients taking SNRIs are associated with changes in LC neurons.
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GUINEA IZQUIERDO, Andrés, GIMÉNEZ, Mònica, MARTÍNEZ ZALACAÍN, Ignacio, CERRO SAN ILDEFONSO, Inés del, CANAL NOGUER, Pol, BLASCO, Gerard, GASCÓN-BAYARRI, Jordi, REÑÉ RAMÍREZ, Ramon, RICO, Imma, CAMINS, Àngels, AGUILERA, Carles, URRETAVIZCAYA SARACHAGA, Mikel, FERRER, Isidro (ferrer abizanda), MENCHÓN MAGRIÑÁ, José manuel, SORIA, Virginia, SORIANO MAS, Carles. Lower Locus Coeruleus MRI intensity in patients with late-life major depression. _PeerJ_. 2021. Vol. 9. [consulta: 15 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/176018]