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Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia_FrontiersInOncology.pdf (5.58 MB)

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Article

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2022-01-31

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cc by (c) Ortiz Maldonado, Valentín et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/197660

Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation

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https://doi.org/10.3389/fonc.2022.828471

Abstract

CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high risk CLL or RT

Subject

Leucèmia limfocítica crònica, Teràpia cel·lular

Subject (English)

Chronic lymphocytic leukemia, Cellular therapy

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

ORTIZ-MALDONADO GIBSON, Valentín, et al. Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation. Frontiers In Oncology. 2022. Vol. 12, num. 828471. ISSN 2234-943X. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/197660

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