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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/99684
The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites
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Sequestration of red blood cells infected with the human malaria
parasite Plasmodium falciparum in organs such as the brain is
considered important for pathogenicity. A similar phenomenon has
been observed in mouse models of malaria, using the rodent
parasite Plasmodium berghei, but it is unclear whether the P.
falciparum proteins known to be involved in this process are
conserved in the rodent parasite. Here we identify the P.
berghei orthologues of two such key factors of P. falciparum,
SBP1 and MAHRP1. Red blood cells infected with P. berghei
parasites lacking SBP1 or MAHRP1a fail to bind the endothelial
receptor CD36 and show reduced sequestration and virulence in
mice. Complementation of the mutant P. berghei parasites with
the respective P. falciparum SBP1 and MAHRP1 orthologues
restores sequestration and virulence. These findings reveal
evolutionary conservation of the machinery underlying
sequestration of divergent malaria parasites and support the
notion that the P. berghei rodent model is an adequate tool for
research on malaria virulence.
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NIZ, Mariana De, et al. The machinery underlying malaria parasite virulence is conserved
between rodent and human malaria parasites. Nature Communications. 2016. Vol. 7, num. 11659. ISSN 2041-1723. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/99684