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2016-05-26

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cc by (c) De Niz et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/99684

The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites

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http://dx.doi.org/10.1038/ncomms11659

Resum

Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores sequestration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence.

Matèries

Malalties parasitàries, Plasmodium falciparum

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Parasitic diseases, Plasmodium falciparum

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Articles publicats en revistes (ISGlobal)
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

NIZ, Mariana de, ULLRICH, Ann-katrin, HEIBER, Arlett, BLANCKE SOARES, Alexandra, PICK, Christian, LYCK, Ruth, KELLER, Derya, KAISER, Gesine, PRADO, Monica, FLEMMING, Sven, PORTILLO OBANDO, Hernando a. del, JANSE, Chris j., HEUSSLER, Volker t., SPIELMANN, Tobias. The machinery underlying malaria parasite virulence is conserved
                between rodent and human malaria parasites. _Nature Communications_. 2016. Vol. 7, núm. 11659. [consulta: 20 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/99684]

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