Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

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dc.contributor.authorPhelan, Catherine M.
dc.contributor.authorKuchenbaecker, Karoline B.
dc.contributor.authorTyrer, Jonathan P.
dc.contributor.authorKar, Siddhartha P.
dc.contributor.authorLawrenson, Kate
dc.contributor.authorWinham, Stacey J.
dc.contributor.authorDennis, Joe
dc.contributor.authorPirie, Ailith
dc.contributor.authorRiggan, Marjorie J.
dc.contributor.authorChornokur, Ganna
dc.contributor.authorEarp, Madalene A.
dc.contributor.authorHildebrandt, Mat
dc.contributor.authorStudy EMBRACE
dc.contributor.authorGlasspool, Rosalind
dc.contributor.authorPeissel, Bernard
dc.contributor.authorMonteiro, Alvaro N.
dc.contributor.authorAloisio, Aimee A. D’
dc.contributor.authorOnland-Moret, N. Charlotte
dc.contributor.authorPiskorz, Anna M.
dc.contributor.authorHuzarski, Tomasz
dc.contributor.authorvan Nieuwenhuysen, Els
dc.contributor.authorChan, Salina B.
dc.contributor.authorTihomirova, Laima
dc.contributor.authorNeuhausen, Susan L.
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorRothstein, Joseph H.
dc.contributor.authorSandler, Dale P.
dc.contributor.authorPujana Genestar, M. Ángel
dc.contributor.authorDao, Fanny
dc.contributor.authorBrooks-Wilson, Angela R.
dc.contributor.authorBean, Yukie
dc.contributor.authorGodwin, Andrew K.
dc.contributor.authorHuang, Ruea-Yea
dc.contributor.authorMazoyer, Sylvie
dc.contributor.authorWebb, Penelope M.
dc.contributor.authorRichardson, Andrea
dc.contributor.authorDansonka-Mieszkowska, Agnieszka
dc.contributor.authorOrsulic, Sandra
dc.contributor.authorKjaer, Susanne Krüger
dc.contributor.authorHahnen, Eric
dc.contributor.authorPezzani, Lidia
dc.contributor.authorNedergaard, Lotte
dc.contributor.authorNussbaum, Robert L.
dc.contributor.authorBogdanova, Natalia V.
dc.contributor.authorKwong, Ava
dc.contributor.authorHazelett, Dennis
dc.contributor.authorHooning, Maartje J.
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorCook, Linda S.
dc.contributor.authorRisch, Harvey A.
dc.contributor.authorKruse, Torben A.
dc.contributor.authorPalli, Domenico
dc.contributor.authorLyra, Paulo C.
dc.contributor.authorMeijers-Heijboer, Hanne
dc.contributor.authorLaitman, Yael
dc.contributor.authorCoetzee, Simon
dc.contributor.authorMoysich, Kirsten B.
dc.contributor.authorLele, Shashikant B.
dc.contributor.authorLambrechts, Diether
dc.contributor.authorZorn, Kristin K.
dc.contributor.authorSalvesen, Helga B.
dc.contributor.authorSzabo, Csilla I.
dc.contributor.authorJensen, Allan
dc.contributor.authorBlankstein, Kenneth
dc.contributor.authorLee, Jong Won
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorBjorge, Line
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorPapi, Laura
dc.contributor.authorDelnatte, Capucine
dc.contributor.authorJames, Paul
dc.contributor.authorFortner, Renée T.
dc.contributor.authorTrabert, Britton
dc.contributor.authorRomm, Jane
dc.contributor.authorShelford, Tameka
dc.contributor.authorRennert, Gad
dc.contributor.authorKelemen, Linda E.
dc.contributor.authorTung, Nadine
dc.contributor.authorTworoger, Shelley S.
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dc.contributor.authorJanavicius, Ramunas
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dc.contributor.authorLissowska, Jolanta
dc.contributor.authorSteinemann, Doris
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dc.contributor.authorKast, Karin
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dc.contributor.authorDoheny, Kimberly F.
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dc.contributor.authorMcNeish, Iain
dc.contributor.authorGerdes, Anne-Marie
dc.contributor.authorLiebrich, Clemens
dc.contributor.authorTea, Muy-Kheng
dc.contributor.authorEdwards, Digna Velez
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dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorTognazzo, Silvia
dc.contributor.authorMulligan, Anna Marie
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dc.contributor.authorSchmutzler, Rita Katharina
dc.contributor.authorSiddiqui, Nadeem
dc.contributor.authorHodgson, Shirley
dc.contributor.authorVratimos, Athanassios
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dc.contributor.authorPark-Simon, Tjoung-Won
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dc.contributor.authorSukiennicki, Grzegorz
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dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorHosking, Karen
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dc.contributor.authorCannioto, Rikki
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dc.contributor.authorPrieur, Fabienne
dc.contributor.authorLarson, Melissa C.
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dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorTerry, Kathryn L.
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dc.contributor.authorLubinski, Jan
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dc.contributor.authorJakubowska, Anna
dc.contributor.authorCescon, Terence
dc.contributor.authorOttini, Laura
dc.contributor.authorHamann, Ute
dc.contributor.authorOsorio, Ana
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dc.contributor.authorPoole, Elizabeth M.
dc.contributor.authorPark, Sue K.
dc.contributor.authorBojesen, Anders
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dc.contributor.authorZiogas, Argyrios
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dc.contributor.authorSenter, Leigha
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dc.contributor.authorLeslie, Goska
dc.contributor.authorHillemanns, Peter
dc.contributor.authorFogarty, Zachary C.
dc.contributor.authorBirrer, Michael J.
dc.contributor.authorHuntsman, David G.
dc.contributor.authorGanz, Patricia A.
dc.contributor.authorFostira, Florentia
dc.contributor.authorSucheston-Campbell, Lara E.
dc.contributor.authorMoes-Sosnowska, Joanna
dc.contributor.authorPaul, James
dc.contributor.authorDomchek, Susan M.
dc.contributor.authorvan ensburg, Elizabeth J.
dc.contributor.authorKupryjanczyk, Jolanta
dc.contributor.authorPike, Malcolm C.
dc.contributor.authorHeetvelde, Mattias Van
dc.contributor.authorBradbury, Angela R.
dc.contributor.authorKim, Sung-Won
dc.contributor.authorBerchuck, Andrew
dc.contributor.authorDíez Gibert, Orland
dc.contributor.authorAzzollini, Jacopo
dc.contributor.authorPoppe, Bruce
dc.contributor.authorMenon, Usha
dc.contributor.authorNess, Roberta B.
dc.contributor.authorMay, Taymaa
dc.contributor.authorTeixeira, Manuel R.
dc.contributor.authorProkofyeva, Darya
dc.contributor.authorPugh, Elizabeth
dc.contributor.authorEilber, Ursula
dc.contributor.authorBuecher, Bruno
dc.contributor.authorHolland, Helene
dc.contributor.authorDing, Yuan Chun
dc.contributor.authorvan der Hout, Annemarie H.
dc.contributor.authorGoldgar, David E.
dc.contributor.authorOng, Kai Ren
dc.contributor.authorDork, Thilo
dc.contributor.authorEeles, Rosalind A.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorHulick, Peter J.
dc.contributor.authorLázaro García, Conxi
dc.contributor.authorSzafron, Lukasz
dc.contributor.authorBrewer, Carole
dc.contributor.authorThompson, Pamela J.
dc.contributor.authorEdwards, Todd L.
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorPedersen, Inge Søkilde
dc.contributor.authorHein, Alexander
dc.contributor.authorGentry-Maharaj, Aleksandra
dc.contributor.authorEllis, Steve
dc.date.accessioned2018-09-10T10:03:53Z
dc.date.available2018-09-10T10:03:53Z
dc.date.issued2017-05-01
dc.date.updated2018-07-24T12:07:58Z
dc.description.abstractTo identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
dc.format.extent36 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid28346442
dc.identifier.urihttps://hdl.handle.net/2445/124402
dc.language.isoeng
dc.publisherNature Publishing
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1038/ng.3826
dc.relation.ispartofNature Genetics, 2017, vol. 49, num. 5, p. 680-691
dc.relation.urihttps://doi.org/10.1038/ng.3826
dc.rightscc-by-nc-sa (c) Phelan et al., 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationCàncer d'ovari
dc.subject.otherOvarian cancer
dc.titleIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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