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2014-02

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/129163

Herpes simplex virus encephalitis is a trigger of brain autoimmunity

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Recurs relacionat

https://doi.org/10.1002/ana.24083

Resum

In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p=0.004; cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity.

Matèries

Encefalitis, Herpes, Autoimmunitat, Malalties cerebrals

Matèries (anglès)

Encephalitis, Herpesvirus diseases, Autoimmunity, Brain diseases

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ARMANGUÉ, Thaís, et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Annals of Neurology. 2013. Vol. 75, num. 2, pags. 317-323. ISSN 0364-5134. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/129163

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