An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

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dc.contributor.authorGandioso, Albert
dc.contributor.authorShaili, Evyenia
dc.contributor.authorMassaguer i Vall-llovera, Anna
dc.contributor.authorArtigas Solé, Gerard
dc.contributor.authorGonzález-Cantó, Alejandro
dc.contributor.authorWoods, Julie A.
dc.contributor.authorSadler, Peter
dc.contributor.authorMarchán Sancho, Vicente
dc.date.accessioned2015-10-08T07:57:06Z
dc.date.available2016-04-21T22:01:22Z
dc.date.issued2015-04-28
dc.date.updated2015-10-08T07:57:06Z
dc.description.abstractA new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control DU-145 human prostate carcinoma cells.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec651927
dc.identifier.issn1359-7345
dc.identifier.pmid25947177
dc.identifier.urihttps://hdl.handle.net/2445/67182
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1039/C5CC03180J
dc.relation.ispartofChemical Communications, 2015, vol. 51, p. 9169-9172
dc.relation.urihttp://dx.doi.org/10.1039/C5CC03180J
dc.rights(c) Gandioso, Albert et al., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationQuimioteràpia del càncer
dc.subject.otherCancer chemotherapy
dc.titleAn integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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