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2012-06-26

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cc by (c) Roura, Esther et al., 2012
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126185

Predictors of human papillomavirus infection in women undergoing routine cervical cancer screening in Spain: the CLEOPATRE study

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https://doi.org/10.1186/1471-2334-12-145

Resum

Background: Human papillomavirus (HPV) is a sexually transmitted infection that may lead to development of precancerous and cancerous lesions of the cervix. The aim of the current study was to investigate sociodemographic, lifestyle, and medical factors for potential associations with cervical HPV infection in women undergoing cervical cancer screening in Spain. Methods: The CLEOPATRE Spain study enrolled 3 261 women aged 18–65 years attending cervical cancer screening across the 17 Autonomous Communities. Liquid-based cervical samples underwent cytological examination and HPV testing. HPV positivity was determined using the Hybrid Capture II assay, and HPV genotyping was conducted using the INNO-LiPA HPV Genotyping Extra assay. Multivariate logistic regression was used to identify putative risk factors for HPV infection. Results: A lifetime number of two or more sexual partners, young age (18–25 years), a history of genital warts, and unmarried status were the strongest independent risk factors for HPV infection of any type. Living in an urban community, country of birth other than Spain, low level of education, and current smoking status were also independent risk factors for HPV infection. A weak inverse association between condom use and HPV infection was observed. Unlike monogamous women, women with two or more lifetime sexual partners showed a lower risk of infection if their current partner was circumcised (P for interaction, 0.005) and a higher risk of infection if they were current smokers (P for interaction, 0.01). Conclusion: This is the first large-scale, country-wide study exploring risk factors for cervical HPV infection in Spain. The data strongly indicate that variables related to sexual behavior are the main risk factors for HPV infection. In addition, in non-monogamous women, circumcision of the partner is associated with a reduced risk and smoking with an increased risk of HPV infection.

Matèries

Papil·lomavirus, Espanya, Factors de risc en les malalties, Càncer de coll uterí, Conducta sexual

Matèries (anglès)

Papillomaviruses, Spain, Risk factors in diseases, Cervix cancer, Sex customs

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ROURA FORNELLS, Esther, IFTNER, Thomas, VIDART, José antonio, KJAER, Susanne krüger, BOSCH JOSÉ, Francesc xavier, MUÑOZ, Nubia, PALACIOS RUIZ, Lucas santiago, RODRIGUEZ, Maria san martin, MORILLO, Carmen, SERRADELL, Laurence, TORCEL PAGNON, Laurence, CORTÉS, Javier, CASTELLSAGUÉ, Xavier, TORNÉ BLADÉ, Aureli, CLEOPATRE Spain  Study Group. Predictors of human papillomavirus infection in women undergoing routine cervical cancer screening in Spain: the CLEOPATRE study. _BMC Infectious Diseases_. 2012. Vol. 12, núm. 145. [consulta: 21 de gener de 2026]. ISSN: 1471-2334. [Disponible a: https://hdl.handle.net/2445/126185]

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