Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/100545
No major host genetic risk factor contributed to A(H1N1)2009 influenza severity
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.
Matèries (anglès)
Citació
Col·leccions
Citació
GARCIA-ETXEBARRIA, Koldo, BRACHO, María alma, GALÁN, Juan carlos, PUMAROLA SUÑÉ, Tomàs, CASTILLA, Jesús, ORTIZ DE LEJARAZU, Raul, RODRÍGUEZ-DOMINGUEZ, Mario, QUINTELA, Inés, BONET, Núria, GARCIA-GARCERÀ, Marc, DOMÍNGUEZ GARCÍA, Àngela, GONZÁLEZ-CANDELAS, Fernando, CALAFELL, Francesc. No major host genetic risk factor contributed to A(H1N1)2009 influenza severity. _PLoS One_. 2015. Vol. 10, núm. 9, pàgs. e0135983. [consulta: 21 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/100545]