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2015-09-17

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cc-by (c) Garcia-Etxebarria, K. et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/100545

No major host genetic risk factor contributed to A(H1N1)2009 influenza severity

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Recurs relacionat

http://dx.doi.org/10.1371/journal.pone.0135983

Resum

While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.

Matèries

Grip, Genòmica, Factors de risc en les malalties, Estudi de casos

Matèries (anglès)

Influenza, Genomics, Risk factors in diseases, Case studies

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

GARCIA-ETXEBARRIA, Koldo, et al. No major host genetic risk factor contributed to A(H1N1)2009 influenza severity. PLoS One. 2015. Vol. 10, num. 9, pags. e0135983. ISSN 1932-6203. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/100545

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