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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/66251
Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
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Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
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ARDANUY TISAIRE, María Carmen, et al. Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain. Emerging Infectious Diseases. 2014. Vol. 20, num. 11, pags. 1848-1856. ISSN 1080-6040. [consulted: 7 of June of 2026]. Available at: https://hdl.handle.net/2445/66251