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2014-11

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Domini públic / Public domain
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/66251

Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain

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Recurs relacionat

http://dx.doi.org/10.3201/eid2011.131215

Resum

Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.

Matèries

Pneumococs, Infeccions per pneumococs, Estreptococs, Resistència als medicaments, Malalties de l'aparell respiratori, Malalties infeccioses, Espanya

Matèries (anglès)

Streptococcus pneumonia, Pneumococcal Infections, Streptococcus, Drug resistance, Respiratory organs diseases, Communicable diseases, Spain

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ARDANUY TISAIRE, María Carmen, et al. Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain. Emerging Infectious Diseases. 2014. Vol. 20, num. 11, pags. 1848-1856. ISSN 1080-6040. [consulted: 23 of May of 2026]. Available at: https://hdl.handle.net/2445/66251

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