Fitxers

899555.pdf (3.27 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2025-10

Llicència de publicació

cc-by (c) Selma-Royo, Marta et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231291

Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.ajcnut.2025.07.030

Resum

Background Despite the importance of gestation period for human health, studies addressing the impact of maternal microbiota on its progression and its modulation by maternal lifestyle are scarce. Although most of the evidence in the field comes from observational studies, we recently described how some lifestyle interventions during pregnancy reduced the small-for-gestational-age (SGA) incidence. We hypothesized the pregnant individual’s microbiome modulation as potential mechanism by which lifestyle interventions could impact gestation progression. Objectives The objectives of this study was to investigate the effect of pregnancy lifestyle interventions, based on a Mediterranean dietary pattern (MD) or Stress Reduction program (SR) that proved to be beneficial in reducing the SGA incidence, on the pregnant individuals’ gut and vaginal microbiota as exploratory outcomes. Methods In a random subsample (n = 351) from a trial including pregnancies randomly allocated into an MD intervention, an SR program, or non-intervention, maternal fecal/vaginal samples were collected at the end of the interventions, and in a subset (n = 85) also at recruitment. Microbiota was profiled by 16S rRNA gene sequencing. Multivariate models evaluated the associations of microbiota with the interventions. Results Mothers included in the study presented a similar gut microbiota profile before the intervention; pregnancy MD intervention influenced the overall structure of gut microbiota, (R2 = 0.008, F = 1.885, P = 0.002), which resulted in enrichment in Firmicutes phylum (Coeff = 0.06, 95% confidence interval [CI]: 0.002, 0.118), related to the increment in health-associated taxa (Lachnospiraceae/Ruminococcaceae families) and other SCFA producers; and diminishment in Campylobacter genus (Coeff = −0.91, 95% CI: −1.361, −0.459). The link of the SR program with gut microbiota was more limited; however, some key components from these families were also affected. Microbial diversity of gut microbiota decreased as pregnancy progressed, with this effect more observable in the mothers that followed the interventions. The interventions have a negligible association with the vaginal microbiota. Conclusions Pregnancy lifestyle interventions influence maternal gut microbiota.

Matèries

Cuina mediterrània, Embaràs, Atenció plena

Matèries (anglès)

Mediterranean cooking, Pregnancy, Mindfulness (Psychology)

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

Citació

SELMA-ROYO, Marta, et al. Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial. The American Journal of Clinical Nutrition. 2025. Vol. 122, num. 4, pags. 1121-1133. ISSN 0002-9165. [consulted: 8 of September of 2026]. Available at: https://hdl.handle.net/2445/231291

Exportar metadades

JSON - METS

Compartir registre