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2023-11-30

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cc by (c) Peñalver Argüeso, Belén et al, 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/205382

Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

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https://doi.org/10.18332/tid/174132

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INTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.RESULTS Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked >= 30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking >= 10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk.CONCLUSIONS Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.

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Hàbit de fumar, Càncer de mama

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Smoking, Breast cancer

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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PEÑALVER ARGÜESO, Belén, GARCÍA ESQUINAS, Esther, CASTELLÓ, Adela, FERNÁNDEZ DE LARREA BAZ, Nerea, CASTAÑO VINYALS, Gemma, AMIANO, Pilar, FERNÁNDEZ VILLA, Tania, GUEVARA, Marcela, FERNÁNDEZ TARDÓN, Guillermo, ALGUACIL, Juan, OBÓN SANTACANA, Mireia, GÓMEZ ACEBO, Inés, PINTO CARBÓ, Marina, MARCOS GRAGERA, Rafael, ARAGONÉS, Nuria, AIZPURUA, Amaia, MARTÍN SÁNCHEZ, Vicente, ARDANAZ, Eva, DIERSSEN SOTOS, Trinidad, JIMÉNEZ MOLEÓN, Jose juan, KOGEVINAS, Manolis, POLLÁN, Marina, PÉREZ GÓMEZ, Beatriz. Smoking history and breast cancer risk by pathological subtype: MCC-Spain study. _Tobacco Induced Diseases_. 2023. Vol. 21, núm. 11, pàgs. 1-16. [consulta: 21 de gener de 2026]. ISSN: 1617-9625. [Disponible a: https://hdl.handle.net/2445/205382]

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