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life-11-00135-v3.pdf (1.2 MB)

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2021-02-10

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cc by (c) Ramiro et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175800

Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke

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https://doi.org/10.3390/life11020135

Resum

Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine hundred and forty-one ischemic stroke patients were prospectively recruited in the Stroke-Chip study. Post-stroke mortality was evaluated during a median 4.8-year follow-up. A 14-biomarker panel was analyzed by immunoassays in blood samples obtained at hospital admission. Biomarkers were normalized and standardized using Z-scores. Multiple Cox regression models were used to identify clinical variables and biomarkers independently associated with long-term mortality and mortality due to stroke. In the multivariate analysis, the independent predictors of long-term mortality were age, female sex, hypertension, glycemia, and baseline National Institutes of Health Stroke Scale (NIHSS) score. Independent blood biomarkers predictive of long-term mortality were endostatin > quartile 2, tumor necrosis factor receptor-1 (TNF-R1) > quartile 2, and interleukin (IL)-6 > quartile 2. The risk of mortality when these three biomarkers were combined increased up to 69%. The addition of the biomarkers to clinical predictors improved the discrimination (integrative discriminative improvement (IDI) 0.022 (0.007-0.048), p < 0.001). Moreover, endostatin > quartile 3 was an independent predictor of mortality due to stroke. Altogether, endostatin, TNF-R1, and IL-6 circulating levels may aid in long-term mortality prediction after stroke.

Matèries

Isquèmia, Marcadors bioquímics, Mortalitat

Matèries (anglès)

Ischemia, Biochemical markers, Mortality

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

RAMIRO, Laura, ABRAIRA, Laura, QUINTANA, Manuel, GARCÍA RODRÍGUEZ, Paula, SANTAMARINA, Estevo, ÁLVAREZ SABÍN, Jose, ZARAGOZA, Josep, HERNÁNDEZ PÉREZ, María, USTRELL, Xavier, LARA, Blanca, TERCEÑO, Mikel, BUSTAMANTE, Alejandro, MONTANER, Joan. Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke. _Life_. 2021. Vol. 11, núm. 2. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/175800]

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