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2024-01-04

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cc by (c) Bastard, Paul et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/207702

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

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https://doi.org/10.1084/jem.20231353

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We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2.

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Autoanticossos, COVID-19

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Autoantibodies, COVID-19

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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BASTARD, Paul, GERVAIS, Adrian, TANIGUCHI, Maki, SAARE, Liisa, SÄREKANNU, Karita, LE VOYER, Tom, PHILIPPOT, Quentin, ROSAIN, Jérémie, BIZIEN, Lucy, ASANO, Takaki, GARCIA PRAT, Marina, JOUANGUY, Emmanuelle, TATSI, Elizabeth barbara, RENIA, Laurent, COBAT, Aurélie, SADIKI ORAYYOU, José miguel, LENDOIRO FUENTES, Marta, COLOBRAN, Roger, RESNICK, Igor, RODRÍGUEZ GALLEGO, Carlos, YAHŞI, Aysun, CASTAGNOLI, Riccardo, PAN-HAMMARSTRÖM, Qiang, CASARI, Giorgio, VARELA GARCÍA, Pablo, BARBEITO CASTIÑEIRAS, Gema, DACOSTA URBIETA, Ana isabel, FILIPPATOS, Filippos, BEN GARCÍA, Miriam, PRANDO, Carolina, HATIPOGLU, Nevin, BONDARENKO, Anastasiia, FROIDURE, Antoine, VIZ LASHERAS, Sandra, MIRONSKA, Kristina, LÓPEZ FRANCO, Montserrat, VINH, Donald c., REY GARCÍA, Susana, COBAT, Aurélie, TIBERGHIEN, Pierre, DUVAL, Xavier, FERNÁNDEZ VILLAVERDE, Juan, BOISSON, Bertrand, BIGGS, Catherine m., DUVLIS, Sotirija, BOUSFIHA, Ahmed a., FELLAY, Jacques, BASTÓN REY, Iria, PESOLE, Graziano, SALAS, Antonio, ZAWADZKI, Pawel, HAMMARSTRÖM, Lennart, BÉZIAT, Vivien, CONDINO NETO, Antonio, PEREZ TUR, Jordi, CONSTANTINESCU, Stefan n., HSIEH, Elena w.y., AGUILERA GUIRAO, Antonio, BORGHESI, Alessandro, PESSION, Andrea, RODRIGUEZ PALMERO, Agusti, Covid Clinicians, ITAN, Yuval, SABORIDO PAZ, Eva, ESCODA, Simon, GUERRA LIÑARES, Beatriz, REY VÁZQUEZ, Sara, ANDREAKOS, Evangelos, FERREIRO IGLESIAS, Rocio, PÉREZ FREIXO, Hugo, NÚÑEZ MASID, Eloína, THORBALL, Christian, SEPPÄNEN, Mikko r.j., MENTRÉ, France, TANCEVSKI, Ivan, AHLIJAH, Gloria, RIVIÈRE, Jacques g., NG, Lisa f.p., Gen Covid Study Group, NOVELLI, Giuseppe, ZATZ, Mayana, TROUILLET ASSANT, Sophie, Covid Human Genetic Effort, COIRA NIETO, Amparo, JABANDZIEV, Petr, CARRAL GARCÍA, María victoria, HAYAKAWA, Seiichi, CURRÁS TUALA, María josé, PERLIN, David s., SOUDEE, Camille, ARSEGUEL, Vincent, GRIMBACHER, Bodo, LÉVY, Romain, FURKAN UDDIN, K.m., BOUSFIHA, Ahmed a., ABOLHASSANI, Hassan, OZCELIK, Tayfun, LEBORÁNS IGLESIAS, Pilar, BOGUNOVIC, Dusan, SAHANIC, Sabina, SERÉN FERNÁNDEZ, Sonia, RIVEIRO BLANCO, Vanessa, GALBÁN RODRÍGUEZ, Cristóbal, GOROCHOV, Guy, SOUMELIS, Vassili, MILNER, Joshua d., TANCEVSKI, Ivan, NUKUI, Yoko, TÜTER ÖZ, Şadiye kübra, HAMMARSTRÖM, Lennart, O’FARRELLY, Cliona, LAU, Yu lung, BRODIN, Petter, CONDINO NETO, Antonio, OKADA, Satoshi, RIVERO CALLE, Irene, AIUTI, Alessandro, BUTTE, Manish j., NEVEN, Bénédicte, SANCHO SHIMIZU, Vanessa, BOLZE, Alexandre, GREGERSEN, Peter k., MARSEGLIA, Gian luigi, SOLER PALACÍN, Pere, SLABY, Ondrej, KISAND, Kai, EL BAKKOURI, Jalila, TEMEL, Şehime gülsün, METIN AKCAN, Ozge, DESAI, Murkesh, PARRA MARTÍNEZ, Alba, TRASTOY PENA, Rocío, TURVEY, Stuart e., OZCELIK, Tayfun, JAVOUHEY, Etienne, ABI HAIDAR, Anthony, ERDENIZ, Emine hafize, ZHANG, Shen ying, KILIÇ, Ahmet osman, SOUTO SANMARTÍN, Pablo, PUJOL, Aurora, SU, Helen c., IMAI, Kohsuke, OZKAYA PARLAKAY, Aslinur, PAPADAKI, Maria, RIVERO VELASCO, Carmen, GIRÁLDEZ VÁZQUEZ, Elena, QUARTIER, Pierre, MEYTS, Isabelle, SLABA, Katerina, LING, Yun, PARDO SECO, Jacobo, OKAMOTO, Keisuke, CEBEY LÓPEZ, Miriam, HALWANI, Rabih, BELOT, Alexandre, BRYCESON, Yenan, SOLER PALACIN, Pere, SCHIDLOWSKI, Laire, CONDE PÁJARO, Mónica, PISCHEDDA, Sara, ABEL, Laurent, ZHANG, Qian, GULHAN, Belgin, ALKAN, Gulsum, GÓMEZ CARBALLA, Alberto, CHRISTODOULOU, John, FRANCO, José luis, CASANOVA, Jean-laurent, REGUEIRO CASUSO, Patricia, PORTELA ROMERO, Manuel, MIGAUD, Mélanie, WAUTERS, Joost, KARBUZ, Adem, POSE REINO, Antonio, TILLMANN, Vallo, SEDIVA, Anna, NAVARRO DE LA CRUZ, Daniel, MARR, Nico, PRADA HERVELLA, Gloria maría, MOGENSEN, Trine h., LUCAS, Carrie l., DROLET, Beth a., HUSAIN, Maya, MEYTS, Isabelle, QUEIRO VERDES, Teresa, TANGYE, Stuart g., REDONDO COLLAZO, Lorenzo, ANDERSON, Mark s., MARTINÓN TORRES, Federico, BAYHAN, Gülsün iclal, SPAAN, András n., TANDJAOUI LAMBIOTTE, Yacine, FERNÁNDEZ PÉREZ, Cristina, MANSOURI, Davood, PÉREZ DE DIEGO, Rebeca, VON BERNUTH, Horst, SHAHROOEI, Mohammed, GARCÍA VICENTE, Luisa, BELLO PADERNE, Xabier, ANDREAKOS, Evangelos, TIPU, Imran, TROYA, Jesus, DOMÍNGUEZ SANTALLA, María jesús, TREVIÑO CASTELLANO, Mercedes, CHEIKH, Nathalie, ARIAS, Andrés a., GÓMEZ RIAL, José, OSTROWSKI, Sisse rye, ALKHATER, Suzan a., GONZÁLEZ GRANADO, Luis ignacio, MARTINÓN TORRES, Federico, HEATH, James r., ARKIN, Lisa m., MENTIS, Alexios fotios a., ABEL, Laurent, MORIO, Tomohiro, KANIK YUKSEK, Saliha, BARIS FELDMAN, Hagit, GÓMEZ CARBALLA, Alberto, BASTARD, Paul, MARÓDI, László, TANAKA, Junko, PÉREZ DEL MOLINO BERNAL, Marisa, COLOBRAN, Roger, BELOT, Alexandre, OKADA, Satoshi, AGUILERA ALBESA, Sergio, NOTARANGELO, Luigi d., ZHANG, Qian, CYRUS, Cyril, LENCE MASSA, Beatriz, ÁLVAREZ ESCUDERO, Julián, SAITO VILLANUEVA, Carla, MORIO, Tomohiro, JARVIS, Erich d., CHROUSOS, George p., COSTA ALCALDE, José javier, CALVIÑO SUÁREZ, Cristina, ELOY, Philippine, TROUILLET ASSANT, Sophie, GARCÍA ALLUT, José luis, UDDIN, Mohammed j., KU, Cheng lung, SHCHERBINA, Anna, JOUANGUY, Emmanuelle, GONZÁLEZ BARCALA, Francisco javier, EMIROGLU, Melike, AMARA, Ali, HAERYNCK, Filomeen, ORTOLÁ DEVESA, Juan bautista, HAGIN, David, KAJA, Elżbieta, SEVKETOGLU, Esra, SNOW, Andrew l., MOGENSEN, Trine h., ABOU TAYOUN, Ahmad, PAZO NÚÑEZ, María, KARAMITROS, Timokratis, RODRÍGUEZ TENREIRO SÁNCHEZ, Carmen, KISAND, Kai, PLANAS, Anna m., PIÑEIRO RODRÍGUEZ, Lidia, ROUSSEL, Lucie, AL MUHSEN, Saleh, MICHOS, Athanasios, DALGARD, Clifton l., ESPINOSA PADILLA, Sara, PUEL, Anne, ELMAS BOZDEMIR, Sefika, EL BAGHDADI, Jamila, BEEK, Diederik van de, KELES, Sevgi, RODRÍGUEZ NÚÑEZ, Nuria, COOPER, Megan a., TSUMURA, Miyuki, NOVELLI, Antonio, TABOADA MUÑIZ, Manuel, PRANDO, Carolina, RODRÍGUEZ GALLEGO, Carlos, VALDÉS CUADRADO, Luis, HAERYNCK, Filomeen, DÍAZ ESTEBAN, Blanca, PETERSON, Pärt, PUJOL, Aurora, PAPE, Jean w., VALENCIA RAMOS, Juan, BRODIN, Petter, AL MULLA, Fahd, PUEL, Anne, QUINTANA MURCI, Lluis, FLORES, Carlos, LÓPEZ LAGO, Ana, HUSEBYE, Eystein, ANTELA LÓPEZ, Antonio, RAMASWAMY, Sathishkumar, CONTI, Francesca, SALAS, Antonio, VILAS IGLESIAS, María soledad. Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children. _Journal of Experimental Medicine_. 2024. Vol. 221, núm. 2. [consulta: 22 de gener de 2026]. ISSN: 1540-9538. [Disponible a: https://hdl.handle.net/2445/207702]

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