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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/140436
Access to indolines from primary phenylethylamines by an unexpected palladium- catalyzed C-H functionalization process
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A new method for the preparation of 2,2-disubstituted indolines from 2-phenylethylamines was developed under Pd catalysis and PhI(OAc)2 as oxidant. Imines derived from 2-pyridinecarboxaldehyde were formed in situ to direct a C-H activation process. The resulting imines were also oxidized to the corresponding amides in the same Pd-catalyzed process to obtain the final indoline as a picolinamide.
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MANCINELLI, Andrea, et al. Access to indolines from primary phenylethylamines by an unexpected palladium- catalyzed C-H functionalization process. RSC Advances. 2019. Vol. 9, num. 47, pags. 27176-27182. ISSN 2046-2069. [consulted: 17 of June of 2026]. Available at: https://hdl.handle.net/2445/140436