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Article

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Accepted version

Publication date

2019-12-30

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/159735

Iron hydride radical reductive alkylation of unactivated alkenes

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https://doi.org/10.1021/acs.orglett.9b04459

Abstract

Iron-catalyzed hydrogen atom transfer-mediated intermolecular C−C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using Et3N, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope.

Subject

Alquens, Hidrogen

Subject (English)

Alkenes, Hydrogen

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citation

SALADRIGAS, Mar, BONJOCH I SESÉ, Josep and BRADSHAW, Ben. Iron hydride radical reductive alkylation of unactivated alkenes. Organic Letters. 2019. Vol. 22, num. 2, pags. 684-688. ISSN 1523-7060. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/159735

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