Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/193181
Long-term strenuous exercise promotes vascular injury by selectively damaging the tunica media: experimental evidence
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise.
Subject (English)
Citation
Citation
RUBIES, Cira, et al. Long-term strenuous exercise promotes vascular injury by selectively damaging the tunica media: experimental evidence. Jacc-Basic To Translational Science. 2022. Vol. 7, num. 7, pags. 681-693. ISSN 2452-302X. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/193181